3,5-Dichloro-2,6-difluoropyridin-4-amine

Base Information

• Chemical Name: 3,5-Dichloro-2,6-difluoropyridin-4-amine
• CAS No.: 2840-00-8
• Molecular Formula: C5H2Cl2F2N2
• Molecular Weight: 198.987
• Hs Code.: 2933399090
• European Community (EC) Number: 220-630-1
• DSSTox Substance ID: DTXSID7062665
• Nikkaji Number: J306.768H
• Wikidata: Q72435688
• Mol file: 2840-00-8.mol

Synonyms:2840-00-8;4-Amino-3,5-dichloro-2,6-difluoropyridine;3,5-Dichloro-2,6-difluoropyridin-4-amine;4-Pyridinamine, 3,5-dichloro-2,6-difluoro-;1-Amino-2,6-dichloro-3,5-difluorobenzene;C5H2Cl2F2N2;EINECS 220-630-1;3,5-dichloro-4-amino-2,6-difluoropyridine;SCHEMBL3569028;DTXSID7062665;C5-H2-Cl2-F2-N2;AMY28257;STR06077;MFCD00011574;AKOS005064014;AC-22561;3,5-Dichloro-2,6-Difluoro-4-Aminopyridine;CS-0113069;FT-0634514;EN300-37174;A26082;W-107046

Chemical Property of 3,5-Dichloro-2,6-difluoropyridin-4-amine

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0035mmHg at 25°C
• Melting Point: 112-114 °C(lit.)
• Refractive Index: 1.567
• Boiling Point: 281.7 °C at 760 mmHg
• PKA: -3.04±0.10(Predicted)
• Flash Point: 124.2 °C
• PSA: 38.91000
• Density: 1.697 g/cm³
• LogP: 2.83000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 197.9563098
• Heavy Atom Count: 11
• Complexity: 134

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-3,5-dichlorodifluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi; N; Xn
• Hazard Codes: Xn,N,Xi
• Statements: 21/22-51/53-36/37/38
• Safety Statements: 36/37-61-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1(=C(C(=NC(=C1Cl)F)F)Cl)N
• Uses: 4-Amino-3,5-dichlorodifluoropyridine, is an intermediate in the synthesis of many chemical compounds, such as Fluroxypyr Ethyl Ester, and Fluroxypyr (F598780).

Technology Process of 3,5-Dichloro-2,6-difluoropyridin-4-amine

There total 6 articles about 3,5-Dichloro-2,6-difluoropyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1) → 4-amino-3,5-dichloro-2,6-difluoropyridine (2840-00-8)

Guidance literature:

With ammonium hydroxide; at 20 ℃;

DOI:10.1081/NCN-100108327

Reference yield: 98.0%

→ 4-amino-3,5-dichloro-2,6-difluoropyridine (2840-00-8)

Guidance literature:

Reference yield: 11.0%

4-azido-3,5-dichloro-2,6-difluoropyridine (17723-18-1) + 1,3,5-trimethyl-benzene (108-67-8) → 1,2-bis(3,5-dimethylphenyl)ethane (63376-64-7) + 4-amino-3,5-dichloro-2,6-difluoropyridine (2840-00-8) + 3,5-dichloro-2,6-difluoro-4-(2,4,6-trimethylphenylamino)pyridine

Guidance literature:

at 160 ℃; for 6h;

DOI:10.1016/S0022-1139(00)80890-8

upstream raw materials:

4-azido-3,5-dichloro-2,6-difluoropyridine

1,3,5-trimethyl-benzene

3,5-dichloro-2,4,6-trifluoropyridine

ammonia

Downstream raw materials:

4-amino-2,6-difluoropyridine

4-amino-3-chloro-2,6-difluoropyridine

4-Amino-3,5-dichlor-2-fluor-6-methoxypyridin

fluroxypyr

Refernces

• 1、 -. "Three nitrogen heterocycle containing 1, 2, 3 - thiadiazole - 5 - a amidine compounds and synthesis". Paragraph 0077; 0078. . Retrieved 2017/08/25.
• 2、 -. "Method for preparing fluroxypyr". Paragraph 0027; 0030. . Retrieved 2017/02/17.