4-(1,2-Diphenylethyl)pyridine

Base Information

• Chemical Name: 4-(1,2-Diphenylethyl)pyridine
• CAS No.: 6634-61-3
• Molecular Formula: C19H17N
• Molecular Weight: 259.351
• NSC Number: 51929
• DSSTox Substance ID: DTXSID90287646
• Nikkaji Number: J1.874.227F
• Pharos Ligand ID: M5YV62HJ7TH6
• ChEMBL ID: CHEMBL342055
• Mol file: 6634-61-3.mol

Synonyms:4-(1,2-diphenylethyl)pyridine;6634-61-3;CHEMBL342055;NSC51929;DTXSID90287646;4-(1,2-Diphenyl-ethyl)-pyridine;BDBM50123256;NSC-51929

Chemical Property of 4-(1,2-Diphenylethyl)pyridine

Chemical Property:

• Vapor Pressure: 2.83E-05mmHg at 25°C
• Boiling Point: 367.8°C at 760 mmHg
• Flash Point: 156.1°C
• Density: 1.08g/cm³
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 259.136099547
• Heavy Atom Count: 20
• Complexity: 257

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(C2=CC=CC=C2)C3=CC=NC=C3

Technology Process of 4-(1,2-Diphenylethyl)pyridine

There total 5 articles about 4-(1,2-Diphenylethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

pyridine-4-carbonitrile (100-48-1) + 2,3-diphenylpropanoic acid (94942-89-9) → 4-(1,2-diphenylethyl)pyridine (6634-61-3)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 25 ℃; for 22h; Inert atmosphere; Irradiation;

DOI:10.1021/acscatal.0c05211

Reference yield:

4-(1-chloro-1,2-diphenylethyl)pyridine (95745-22-5) → 4-(1,2-diphenylethyl)pyridine (6634-61-3)

Guidance literature:

With lithium; In tetrahydrofuran; a) -65 deg C, 1 h, b) 25 deg C, 3 h;

DOI:10.1021/jo00229a001

Reference yield:

4-benzyl pyridine (2116-65-6) + benzyl chloride (100-44-7) → 4-(1,2-diphenylethyl)pyridine (6634-61-3)

Guidance literature:

With n-butyllithium; Multistep reaction; 1.) diethyl ether, hexane, 25 deg C, 45 min, 2.) diethyl ether, hexane, 0 deg C, 3 h;

DOI:10.1021/jo00229a001

upstream raw materials:

4-benzyl pyridine

benzyl chloride

4-(2-chloro-1,1-diphenylethyl)pyridine

4-(1-chloro-1,2-diphenylethyl)pyridine

Refernces

• 1、 Eisch, John J.,Kovacs, Csaba A.,Chobe, Prabodh,Boleslawski, Marek P.. "Carbon-Skeletal Anionic and Radical Sigmatropic Rearrangements: Group Migratory Aptitudes as a Probe of Charge Type in the 1,2-Shifts of β-Phenyl-β-(2-pyridyl)- and β-Phenyl-β-(4-pyridyl)ethyl Systems". . p. 4427 - 4437. Retrieved 2007/10/02.