pent-1-yn-3-one

Base Information

• Chemical Name: pent-1-yn-3-one
• CAS No.: 16469-62-8
• Molecular Formula: C5H6 O
• Molecular Weight: 82.102
• Mol file: 16469-62-8.mol

Synonyms:Ethylethynyl ketone; Ethynyl ethyl ketone

Chemical Property of pent-1-yn-3-one

Chemical Property:

• Vapor Pressure: 23.3mmHg at 25°C
• Boiling Point: 110.9°Cat760mmHg
• Flash Point: 30.1°C
• Density: 0.892g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of pent-1-yn-3-one

There total 4 articles about pent-1-yn-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pent-1-yn-3-ol (4187-86-4) → pent-1-yn-3-one (16469-62-8)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; acetone;

DOI:10.1039/jr9520003839 DOI:10.1039/jr9520001437

Reference yield:

propionyl chloride (79-03-8) + Bis(trimethylsilyl)ethyne (14630-40-1) → pent-1-yn-3-one (16469-62-8)

Guidance literature:

propionyl chloride; Bis(trimethylsilyl)ethyne; With aluminium trichloride; In dichloromethane; at 0 - 20 ℃; for 4h;

With tetrabutyl-ammonium chloride; sodium fluoride; In diethyl ether; water;

DOI:10.1016/S0968-0896(01)00073-6

Reference yield:

1-(trimethylsilyl)-1-pentyne-3-one (18387-58-1) → pent-1-yn-3-one (16469-62-8)

Guidance literature:

With tetrabutyl-ammonium chloride; sodium fluoride; In diethyl ether;

DOI:10.1039/b001329n

upstream raw materials:

pent-1-yn-3-ol

1-(trimethylsilyl)-1-pentyne-3-one

propionyl chloride

Bis(trimethylsilyl)ethyne

Downstream raw materials:

C₃₀H₃₂O₂

pent-1-yn-3-ol

β-Triaethylstannylvinylaethylaether

Refernces

• 1、 Zhang, Mengqi,Zhai, Yongyan,Ru, Shi,Zang, Dejin,Han, Sheng,Yu, Han,Wei, Yongge. "Highly practical and efficient preparation of aldehydes and ketones from aerobic oxidation of alcohols with an inorganic-ligand supported iodine catalyst". supporting information. p. 10164 - 10167. Retrieved 2018/09/13.
• 2、 Heiss, Christian,Laivenieks, Maris,Zeikus,Phillips, Robert S.. "Mutation of cysteine-295 to alanine in secondary alcohol dehydrogenase from thermoanaerobacter ethanolicus affects the enantioselectivity and substrate specificity of ketone reductions". . p. 1659 - 1666. Retrieved 2007/10/03.