1-benzyl 4-tert-butyl 2-Methylpiperazine-1,4-dicarboxylate

Base Information

• Chemical Name: 1-benzyl 4-tert-butyl 2-Methylpiperazine-1,4-dicarboxylate
• CAS No.: 502649-21-0
• Molecular Formula: C18H26N2O4
• Molecular Weight: 334.41000
• Mol file: 502649-21-0.mol

Synonyms:1-benzyl 4-tert-butyl 2-methylpiperazine-1,4-dicarboxylate;

Chemical Property of 1-benzyl 4-tert-butyl 2-Methylpiperazine-1,4-dicarboxylate

Chemical Property:

• Boiling Point: 435.4±33.0 °C(Predicted)
• PKA: -0.25±0.70(Predicted)
• PSA: 59.08000
• Density: 1.137±0.06 g/cm3(Predicted)
• LogP: 3.14020

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Benzyl4-tert-butyl2-methylpiperazine-1,4-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzyl 4-tert-butyl 2-Methylpiperazine-1,4-dicarboxylate

There total 4 articles about 1-benzyl 4-tert-butyl 2-Methylpiperazine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 1-benzyl 4-(tert-butyl) (R)-2-methylpiperazine-1,4-dicarboxylate (1163793-25-6,1163793-31-4,502649-21-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 20h; Inert atmosphere;

Reference yield: 99.0%

benzyl chloroformate (501-53-1,94274-21-2) + (S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (147081-29-6) → 1-benzyl 4-(tert-butyl) (S)-2-methylpiperazine-1,4-dicarboxylate (1163793-31-4,502649-21-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 20h; Inert atmosphere;

Reference yield: 53.0%

1,1'-carbonyldiimidazole (530-62-1) + benzyl alcohol (100-51-6,185532-71-2) + (R)-tert-butyl 3-methylpiperazine-1-carboxylate (163765-44-4) → 1-benzyl 4-(tert-butyl) (R)-2-methylpiperazine-1,4-dicarboxylate (1163793-25-6,1163793-31-4,502649-21-0)

Guidance literature:

1,1'-carbonyldiimidazole; benzyl alcohol; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.333333h; Inert atmosphere;

(R)-tert-butyl 3-methylpiperazine-1-carboxylate; In tetrahydrofuran; at 75 ℃; for 26h; Inert atmosphere;

upstream raw materials:

benzyl chloroformate

(R)-tert-butyl 3-methylpiperazine-1-carboxylate

1,1'-carbonyldiimidazole

benzyl alcohol

Refernces

• 1、 -. "Aromatic heterocyclic derivatives and applications of aromatic heterocyclic derivatives in medicines". Paragraph 0954-0956. . Retrieved 2016/10/09.
• 2、 -. "CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS". Page/Page column 108. . Retrieved 2010/11/27.