3,5-DIMETHOXYBENZHYDRAZIDE

Base Information

• Chemical Name: 3,5-DIMETHOXYBENZHYDRAZIDE
• CAS No.: 51707-38-1
• Molecular Formula: C9H12 N2 O3
• Molecular Weight: 196.206
• Hs Code.: 2928000090
• Mol file: 51707-38-1.mol

Synonyms:3,5-Dimethoxybenzenecarbohydrazide;3,5-Dimethoxybenzhydrazide; 3,5-Dimethoxybenzohydrazide; 3,5-Dimethoxybenzoicacid hydrazide; 3,5-Dimethoxybenzoic hydrazide; 3,5-Dimethoxybenzoylhydrazine;NSC 525793

Chemical Property of 3,5-DIMETHOXYBENZHYDRAZIDE

Chemical Property:

• Melting Point: 143-144°C
• Boiling Point: °Cat760mmHg
• PKA: 11.78±0.10(Predicted)
• Flash Point: °C
• PSA: 73.58000
• Density: 1.189 g/cm³
• LogP: 1.39850

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Dimethoxybenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIMETHOXYBENZHYDRAZIDE

There total 5 articles about 3,5-DIMETHOXYBENZHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

methyl 3,5-dimethoxybenzoate (2150-37-0) → 3,5-dimethoxy-benzoic acid hydrazide (51707-38-1)

Guidance literature:

With hydrazine hydrate; for 3h; Heating;

Reference yield: 78.0%

ethyl 3,5-dimethoxybenzoate (17275-82-0) → 3,5-dimethoxy-benzoic acid hydrazide (51707-38-1)

Guidance literature:

With hydrazine hydrate; for 2h; Heating;

Reference yield:

3,5-dimethoxybenzoic acid (1132-21-4) → 3,5-dimethoxy-benzoic acid hydrazide (51707-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.8 percent / H₂SO₄

2: 93.3 percent / N₂H₄*H₂O / 3 h / Heating

With sulfuric acid; hydrazine hydrate;

upstream raw materials:

ethyl 3,5-dimethoxybenzoate

methyl 3,5-dimethoxybenzoate

3,5-Dihydroxybenzoic acid

3,5-dimethoxybenzoic acid

Downstream raw materials:

5-(3,5-dimethoxy-phenyl)-[1,3,4]oxadiazol-2-ylamine

N-[5-(3,5-dimethoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-methanesulfonamide

N-[5-(3,5-dimethoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-toluene-4-sulfonamide

3-[(3,5-dimethoxy-benzoylhydrazono)-methyl]-rifamycin

Refernces

• 1、 -. "Hydrazide compounds". Paragraph 0088; 0095; 0097; 0098. . Retrieved 2019/10/01.
• 2、 Wang, Zi-Zhen,Sun, Wen-Xue,Wang, Xue,Zhang, Ya-Han,Qiu, Han-Yue,Qi, Jin-Liang,Pang, Yan-Jun,Lu, Gui-Hua,Wang, Xiao-Ming,Yu, Fu-Gen,Yang, Yong-Hua. "Design, synthesis, biological evaluation, and 3D-QSAR analysis of podophyllotoxin–dioxazole combination as tubulin targeting anticancer agents". . p. 236 - 243. Retrieved 2017/07/13.