DL-N-BENZOYL-2-BENZYLSERINE

Base Information

• Chemical Name: DL-N-BENZOYL-2-BENZYLSERINE
• CAS No.: 52421-48-4
• Molecular Formula: C17H16NO4
• Molecular Weight: 299.326
• Hs Code.: 2924299090
• Mol file: 52421-48-4.mol

Synonyms:DL-N-BENZOYL-2-BENZYLSERINE;DL-2-BENZOYLAMINO-2-HYDROXYMETHYL-3-PHENYLPROPIONIC ACID

Chemical Property of DL-N-BENZOYL-2-BENZYLSERINE

Chemical Property:

• Appearance/Colour: white
• Vapor Pressure: 4.25E-15mmHg at 25°C
• Melting Point: 160-162 ºC
• Refractive Index: 1.5400 (estimate)
• Boiling Point: 597 ºC at 760 mmHg
• Flash Point: 314.8 ºC
• PSA: 86.63000
• Density: g/cm³
• LogP: 1.86570

Purity/Quality:

99% ^*data from raw suppliers

DL-N-BENZOYL-2-BENZYLSERINE 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-N-BENZOYL-2-BENZYLSERINE

There total 3 articles about DL-N-BENZOYL-2-BENZYLSERINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(RS)-5-benzoylamino-5-benzyl-4-oxo-1,3-dioxane (51127-28-7) → (RS)-2-benzoylamino-2-benzyl-3-hydroxypropanoic acid (52421-48-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 1h;

Reference yield:

DL-N-benzoylphenylalanine (2566-22-5,2901-76-0,37002-52-1) → (RS)-2-benzoylamino-2-benzyl-3-hydroxypropanoic acid (52421-48-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Ac₂O / 1 h / 95 °C

2: 121 g / pyridine / H₂O / 12 h / 20 °C

3: 89.2 percent / aq. NaOH / dioxane / 1 h / 20 °C

With pyridine; sodium hydroxide; acetic anhydride; In 1,4-dioxane; water;

DOI:10.1248/cpb.50.1362

Reference yield:

4-benzyl-2-phenyl-2-oxazolin-5-one (5874-61-3,21453-79-2,51127-19-6,75658-67-2) → (RS)-2-benzoylamino-2-benzyl-3-hydroxypropanoic acid (52421-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 121 g / pyridine / H₂O / 12 h / 20 °C

2: 89.2 percent / aq. NaOH / dioxane / 1 h / 20 °C

With pyridine; sodium hydroxide; In 1,4-dioxane; water;

DOI:10.1248/cpb.50.1362

upstream raw materials:

(RS)-5-benzoylamino-5-benzyl-4-oxo-1,3-dioxane

4-benzyl-2-phenyl-2-oxazolin-5-one

DL-N-benzoylphenylalanine

Downstream raw materials:

(S)-α-(hydroxymethyl)-D-phenylalanine

(R)-2-amino-3-hydroxy-2-benzylpropionic acid

(S)-2-benzoylamino-2-benzyl-3-tosylpropanoic acid

(R)-2-benzoylamino-2-methyl-3-phenylpropanoic acid

Refernces

• 1、 Olma. "α-Hydroxymethylphenylglycine and α-hydroxymethylphenylalanine: Synthesis, resolution, and absolute configuration". . p. 1442 - 1447. Retrieved 2007/10/03.