7-AMino NiMetazepaM

Base Information

• Chemical Name: 7-AMino NiMetazepaM
• CAS No.: 4959-16-4
• Molecular Formula: C16H15N3O
• Molecular Weight: 265.31
• Mol file: 4959-16-4.mol

Synonyms:7-amino-5-phenyl-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one;7-Amino Nimetazepam;Ro 05-3418;7-Amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one;Ro 05-4318;

Chemical Property of 7-AMino NiMetazepaM

Chemical Property:

• Melting Point: 227-22-9°C (dec.)
• Boiling Point: 540.0±50.0 °C(Predicted)
• PKA: 4.25±0.20(Predicted)
• Flash Point: 2℃
• PSA: 58.69000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 2.16440
• Storage Temp.: Controlled Substance, -20?C Freezer

Purity/Quality:

NLT 98% ^*data from raw suppliers

7-Aminonimetazepam solution 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36
• Safety Statements: 16-36/37

MSDS Files:

Useful:

• Description: 7-Aminonimetazepam (Item No. 18353) is an analytical reference material that is structurally categorized as a benzodiazepine. It is a metabolite of nimetazepam (Item Nos. 19206 | 18352) that can be detected in urine specimens following nimetazepam use. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
• Uses: A metabolite of Nimetazepam

Technology Process of 7-AMino NiMetazepaM

There total 2 articles about 7-AMino NiMetazepaM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nimetazepam (2011-67-8) → 7-amino-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one (4959-16-4)

Guidance literature:

In water; acetonitrile; Product distribution; determination by the products of electrochem. reduction; anode comptmt.: 0.01M HCl; cathode comptmt.: 0.1M CRBr(H₂O)5⁽²⁺⁾ - 1.5M HCl;

Reference yield:

→ 7-amino-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one (4959-16-4)

Guidance literature:

Benzophenon 4, N2H4;

Reference yield: 58.0%

Ethyl hydrogen suberate (14113-01-0) + 7-amino-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one (4959-16-4) → ethyl 8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-7-ylamino)-8-oxooctanoate (1082051-80-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃; for 72h;

DOI:10.1016/j.bmcl.2008.07.119

upstream raw materials:

nimetazepam

Downstream raw materials:

ethyl 8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-7-ylamino)-8-oxooctanoate

7-iodo-1-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

Refernces

• 1、 -. "5-PHENYL-LH-BENZ0 [E] [1, 4] DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS". Page/Page column 14-15. . Retrieved 2009/07/25.
• 2、 Al-Daher, I. M.,Kratochvil, B.. "Coulometric determination of several water-insoluble aromatic nitro compounds with electrogenerated chromium(II)". . p. 3346 - 3349. Retrieved 2007/10/02.