N,N-Diphenylpyridin-2-amine

Base Information

• Chemical Name: N,N-Diphenylpyridin-2-amine
• CAS No.: 50910-08-2
• Molecular Formula: C17H14N2
• Molecular Weight: 246.312
• DSSTox Substance ID: DTXSID90477944
• Nikkaji Number: J1.679.480E
• Wikidata: Q82311026
• Mol file: 50910-08-2.mol

Synonyms:N,N-DIPHENYLPYRIDIN-2-AMINE;50910-08-2;2-Pyridinamine, N,N-diphenyl-;2-pyridyldiphenylamine;cis-diphenyl pyridineamine;2-N,N-Diphenylaminopyridine;SCHEMBL4647647;DTXSID90477944;YKNDJWVBAAZMDC-UHFFFAOYSA-N;MFCD32690959;SY264805

Chemical Property of N,N-Diphenylpyridin-2-amine

Chemical Property:

• PSA: 16.13000
• LogP: 4.55140
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 246.115698455
• Heavy Atom Count: 19
• Complexity: 236

Purity/Quality:

98% ^*data from raw suppliers

2-Pyridinamine,N,N-diphenyl- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=CC=CC=N3

Technology Process of N,N-Diphenylpyridin-2-amine

There total 18 articles about N,N-Diphenylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloropyridine (109-09-1) + diphenylamine (122-39-4) → 2-N,N-diphenylaminopyridine (50910-08-2)

Guidance literature:

With sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; P(i-BuNCH₂CH₂)3N; In toluene; at 100 ℃; for 20h;

DOI:10.1021/jo048716q

Reference yield: 99.0%

2-bromo-pyridine (109-04-6) + diphenylamine (122-39-4) → 2-N,N-diphenylaminopyridine (50910-08-2)

Guidance literature:

With sodium t-butanolate; palladium diacetate; In toluene; at 80 ℃; for 24h;

DOI:10.1021/jo702367k

Reference yield: 90.0%

N,N-diphenylpyridine-2-sulfonamide (370839-63-7) → 2-N,N-diphenylaminopyridine (50910-08-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; triphenylborane; 3,4-thiene-2,3-diylbis(dicyclohexylphosphine); sodium t-butanolate; In 5,5-dimethyl-1,3-cyclohexadiene; at 60 ℃; for 16h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/acs.joc.0c00009

upstream raw materials:

2-aminopyridine

bromobenzene

iodobenzene

2-bromo-pyridine

Refernces

• 1、 Chen, Xuemeng,Jia, Xiuwen,Kramer, S?ren,Li, Yue,Lian, Zhong,Liu, Jiangjun,Sun, Haotian. "Nickel-Catalyzed Intramolecular Desulfitative C - N Coupling: A Synthesis of Aromatic Amines". . p. 5702 - 5711. Retrieved 2020/05/19.
• 2、 -. "A 1 - (2- [...] ) b cyclohexyl phosphine and its preparation method and application (by machine translation)". Paragraph 0073-0077; 0082. . Retrieved 2016/12/01.