Furan, 2,3-dimethyl-4-phenyl-

Base Information

• Chemical Name: Furan, 2,3-dimethyl-4-phenyl-
• CAS No.: 5109-66-0
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Mol file: 5109-66-0.mol

Synonyms:

Chemical Property of Furan, 2,3-dimethyl-4-phenyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Furan, 2,3-dimethyl-4-phenyl-

There total 4 articles about Furan, 2,3-dimethyl-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

α-bromoacetophenone (70-11-1) + 3-Tributylstannanyl-butan-2-one (17795-76-5) → 2,3-Dimethyl-4-phenylfuran (5109-66-0)

Guidance literature:

In toluene; at 80 ℃; for 20h;

DOI:10.1039/c39830000989

Reference yield: 57.0%

1-Bromo-2-butyne (3355-28-0) + α-bromoacetophenone (70-11-1) → 2,3-Dimethyl-4-phenylfuran (5109-66-0)

Guidance literature:

1-Bromo-2-butyne; α-bromoacetophenone; With indium; In tetrahydrofuran; water; at 20 ℃;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2014.06.107

Reference yield:

2,3-dimethylfuran (14920-89-9) + iodobenzene (591-50-4) → 2,3-dimethyl-5-phenylfuran (73186-37-5) + 2,3-Dimethyl-4-phenylfuran (5109-66-0)

Guidance literature:

With C₄₁H₃₆N₂O₅P₂Pd₂; silver carbonate; In toluene; at 120 ℃; for 15h; Overall yield = 10 %; regioselective reaction;

DOI:10.3987/COM-17-13824

upstream raw materials:

α-bromoacetophenone

3-Tributylstannanyl-butan-2-one

1-Bromo-2-butyne

2,3-dimethylfuran

Refernces

• 1、 Lin, Mei-Huey,Kuo, Chung-Kai,Huang, Yen-Chih,Tsai, Yu-Ting,Tsai, Chang-Hsien,Liang, Kung-Yu,Li, Yi-Syuan,Chuang, Tsung-Hsun. "Indium-mediated allenylation of arylacyl bromides in a route for the synthesis of substituted furans". . p. 5513 - 5518. Retrieved 2015/03/30.