1H-Pyrrole, 1-benzoyl-

Base Information

• Chemical Name: 1H-Pyrrole, 1-benzoyl-
• CAS No.: 5145-65-3
• Molecular Formula: C11H9NO
• Molecular Weight: 171.199
• Mol file: 5145-65-3.mol

Synonyms:

Chemical Property of 1H-Pyrrole, 1-benzoyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole, 1-benzoyl-

There total 28 articles about 1H-Pyrrole, 1-benzoyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

pyrrole (109-97-7,30604-81-0) + benzoyl chloride (98-88-4) → N-benzoylpyrrole (5145-65-3)

Guidance literature:

With potassium hydroxide; 1-butyl-3-methylimidazolium Tetrafluoroborate; at 80 ℃; for 1h;

DOI:10.1055/s-2004-829182

Reference yield: 92.0%

pyrrole (109-97-7,30604-81-0) + bromobenzene (108-86-1,52753-63-6) + carbon monoxide (201230-82-2) → N-benzoylpyrrole (5145-65-3)

Guidance literature:

With potassium phosphate; palladium diacetate; triphenylphosphine; In tetrahydrofuran; at 60 ℃;

DOI:10.1021/jo2022444

Reference yield: 91.0%

N,N-diallylbenzamide (10283-70-2) → N-benzoylpyrrole (5145-65-3)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; oxygen; copper(ll) bromide; In toluene; at 110 ℃; for 24h; under 760.051 Torr; Schlenk technique;

DOI:10.1055/s-0039-1690002

upstream raw materials:

potassium pyrrolide

benzoyl chloride

pyrrole

carbon monoxide

Downstream raw materials:

1-benzyl-1H-pyrrole

2-acetyl-N-benzoylpyrrole

benzophenone

4-Methylbenzophenone

Refernces

• 1、 Ghinato, Simone,Territo, Davide,Maranzana, Andrea,Capriati, Vito,Blangetti, Marco,Prandi, Cristina. "A Fast and General Route to Ketones from Amides and Organolithium Compounds under Aerobic Conditions: Synthetic and Mechanistic Aspects". supporting information. p. 2868 - 2874. Retrieved 2021/01/21.
• 2、 Chen, Weiqiang,Li, Hui-Jing,Li, Qin-Ying,Wu, Yan-Chao. "Direct oxidative coupling of: N -acyl pyrroles with alkenes by ruthenium(ii)-catalyzed regioselective C2-alkenylation". supporting information. p. 500 - 513. Retrieved 2020/01/30.