2-Methoxy-1-ethanesulfonyl Chloride

Base Information

• Chemical Name: 2-Methoxy-1-ethanesulfonyl Chloride
• CAS No.: 51517-01-2
• Molecular Formula: C3H7ClO3S
• Molecular Weight: 158.606
• Hs Code.: 2909199090
• European Community (EC) Number: 829-893-2
• DSSTox Substance ID: DTXSID60541843
• Wikidata: Q72489774
• Mol file: 51517-01-2.mol

Synonyms:2-Methoxy-1-ethanesulfonyl Chloride;51517-01-2;2-METHOXYETHANESULFONYL CHLORIDE;2-methoxyethane-1-sulfonyl chloride;MFCD10032391;2-METHOXYETHYLSULFONYL CHLORIDE;Ethanesulfonyl chloride, 2-methoxy-;SCHEMBL1411980;2-Methoxyethyl sulfonyl chloride;2-methoxy-ethanesulfonyl chloride;2-methoxyethane sulfonyl chloride;DTXSID60541843;DUNNNVSEUCJEOY-UHFFFAOYSA-N;AMY20215;BCA51701;2-(methyloxy)ethanesulfonyl chloride;2-METHOXYETHANESULFONYLCHLORIDE;AKOS009158719;AB56111;BS-12887;SY008165;EN300-55176;2-methoxyethane-1-sulfonyl chloride, AldrichCPR;A871253;2-Methox2-Methoxyethanesulfonyl chloridey-1-ethanesulfonyl Chloride

Chemical Property of 2-Methoxy-1-ethanesulfonyl Chloride

Chemical Property:

• Vapor Pressure: 0.71mmHg at 25°C
• Boiling Point: 191.563oC at 760 mmHg
• Flash Point: 69.655oC
• PSA: 51.75000
• Density: 1.357g/cm3
• LogP: 1.28220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 157.9804429
• Heavy Atom Count: 8
• Complexity: 133

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxy-1-ethanesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCS(=O)(=O)Cl

Technology Process of 2-Methoxy-1-ethanesulfonyl Chloride

There total 10 articles about 2-Methoxy-1-ethanesulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

sodium 2-methoxyethanesulfonate (77281-03-9) → 2-methoxyethane-1-sulfonyl chloride (51517-01-2)

Guidance literature:

With trichlorophosphate; at 20 - 110 ℃; for 24h;

Reference yield: 77.0%

2-methoxy-ethanol (109-86-4,95507-80-5) → 2-methoxyethane-1-sulfonyl chloride (51517-01-2)

Guidance literature:

2-methoxy-ethanol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 10 ℃; Inert atmosphere;

With Sodium thiosulfate pentahydrate; In water; at 80 - 85 ℃; for 2 - 2.5h;

With 1,3-dichloro-5,5-dimethylhydantoin; In water; acetic acid; at 23 - 28 ℃;

Reference yield: 67.0%

thiourea (17356-08-0) + 2-Bromoethyl methyl ether (6482-24-2) → 2-methoxyethane-1-sulfonyl chloride (51517-01-2)

Guidance literature:

thiourea; 2-Bromoethyl methyl ether; In ethanol; for 1h; Reflux;

With hydrogenchloride; N-chloro-succinimide; water; In acetonitrile; at 10 - 20 ℃; for 0.25h;

DOI:10.1016/j.ejmech.2020.112963

upstream raw materials:

vinylsulfonyl chloride

sodium methylate

2-ethansulfonsaeure-ethylester

sodium 2-methoxyethanesulfonate

Refernces

• 1、 -. "THIAZOLIDINONE COMPOUNDS AND USE THEREOF". Paragraph 1248-1248. . Retrieved 2017/09/21.
• 2、 -. "Inhibitor for dipeptidyl peptidase-IV". Paragraph 0137-0140. . Retrieved 2017/08/28.