Benzenemethanesulfinic acid, sodium salt

Base Information

• Chemical Name: Benzenemethanesulfinic acid, sodium salt
• CAS No.: 51793-64-7
• Molecular Formula: C7H8O2S.Na
• Molecular Weight: 178.187
• Mol file: 51793-64-7.mol

Synonyms:2,6-Dimethoxy-3H-pyrimidin-4-thion;

Chemical Property of Benzenemethanesulfinic acid, sodium salt

Chemical Property:

• PSA: 79.23000
• LogP: 1.15640

Purity/Quality:

SodiumPhenylmethanesulfinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sodium Phenylmethanesulfinate is used in preparation of (E)-1-phenyl-4-sulfonylbut-1-ene compounds.

Technology Process of Benzenemethanesulfinic acid, sodium salt

There total 7 articles about Benzenemethanesulfinic acid, sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-phenylmethanesulfonyl-benzothiazole (67219-33-4) → sodium α-toluenesulfinate (51793-64-7)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 20 ℃; Reagent/catalyst;

DOI:10.1021/acs.orglett.7b01693

Reference yield: 77.0%

N-benzyl-2,4,6-triphenylpyridinium tetrafluoroborate (66310-10-9) → sodium α-toluenesulfinate (51793-64-7)

Guidance literature:

N-benzyl-2,4,6-triphenylpyridinium tetrafluoroborate; With 1,4-diazabicyclo[2.2.2]octane-triethylenediamine-bis(sulfur dioxide); diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; triethylamine; In N,N-dimethyl acetamide; at 25 ℃; for 16h; Irradiation; Inert atmosphere;

With phosphoric acid; sodium carbonate; In N,N-dimethyl acetamide; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03194

Reference yield: 71.0%

2-(phenylmethylsulfinyl)pyridine N-oxide (62381-90-2) → 2-ethoxylpyridine N-oxide (3445-09-8) + 2-(benzylsulfanyl)pyridine 1-oxide (3915-60-4) + sodium α-toluenesulfinate (51793-64-7)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.5h;

upstream raw materials:

2-(phenylmethylsulfinyl)pyridine N-oxide

2-phenylmethanesulfonyl-benzothiazole

2-benzylthiobenzothiazole

benzenesulfonyl chloride

Downstream raw materials:

(((3-methylbut-2-en-1-yl)sulfonyl)methyl)benzene

(1-(benzylsulfonyl)ethyl)benzene

N-benzyl-1-phenylmethanesulfonamide

N-cyclohexyl-1-phenylmethanesulfonamide

Refernces

• 1、 Gómez, José Enrique,Cristòfol, àlex,Kleij, Arjan W.. "Copper-Catalyzed Enantioselective Construction of Tertiary Propargylic Sulfones". supporting information. p. 3903 - 3907. Retrieved 2019/02/24.
• 2、 Liu, Yanan,Xie, Peizhong,Sun, Zuolian,Wo, Xiangyang,Gao, Cuiqing,Fu, Weishan,Loh, Teck-Peng. "Direct Substitution of Secondary and Tertiary Alcohols to Generate Sulfones under Catalyst- and Additive-Free Conditions". supporting information. p. 5353 - 5356. Retrieved 2018/09/13.