N,N-Diethylbenzhydrylamine

Base Information

• Chemical Name: N,N-Diethylbenzhydrylamine
• CAS No.: 519-72-2
• Molecular Formula: C17H21N
• Molecular Weight: 239.36
• Hs Code.: 2921499090
• UNII: VSP40J0324
• Nikkaji Number: J6.596J
• Wikidata: Q27292003
• Mol file: 519-72-2.mol

Synonyms:N,N-Diethylbenzhydrylamine;N,N-Diethylbenzhydrylamine [MI];UNII-VSP40J0324;VSP40J0324;519-72-2;Benzenemethanamine, N,N-diethyl-alpha-phenyl-;benzhydryl-diethyl-amine;diethylaminodiphenylmethane;N-benzhydryl-N-ethylethanamine;N-(diphenylmethyl)-diethylamine;SCHEMBL1760781;N,N-Diethyl-alpha-phenylbenzenemethanamine;Q27292003;BENZENEMETHANAMINE, N,N-DIETHYL-.ALPHA.-PHENYL-

Chemical Property of N,N-Diethylbenzhydrylamine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 56° (Maxim, Mavrodineanu); mp 58-59° [Sommelet, Compt. Rend. 175, 1149 (1922)]; mp 61° [Titov, C.A. 43, 4217 (1949)]
• Refractive Index: 1.5000 (estimate)
• Boiling Point: bp17 170°
• PKA: 8.88±0.25(Predicted)
• PSA: 3.24000
• Density: 1.0137 (rough estimate)
• LogP: 4.11780
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 239.167399674
• Heavy Atom Count: 18
• Complexity: 192

Purity/Quality:

98%min ^*data from raw suppliers

N,N-DIETHYL BENZHYDRYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)C(C1=CC=CC=C1)C2=CC=CC=C2
• Uses: In the detection of nitrates.

Technology Process of N,N-Diethylbenzhydrylamine

There total 9 articles about N,N-Diethylbenzhydrylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.2%

sodium tris(acetoxy)borohydride (56553-60-7) + Benzhydrylamine (91-00-9) → N-(diphenylmethyl)acetamide (5267-35-6) + diethyl-benzhydryl-amine (519-72-2)

Guidance literature:

In acetonitrile; at 60 ℃; for 15h;

DOI:10.1016/j.tetlet.2020.151919

Reference yield: 81.0%

diethylamine (109-89-7) + Bromodiphenylmethane (776-74-9) → diethyl-benzhydryl-amine (519-72-2)

Guidance literature:

In nitromethane; at 97 ℃; for 0.333333h;

Reference yield: 76.0%

diphenylzinc (1078-58-6) + N,N-diethyl-α-methoxy-benzenemethanamine → diethyl-benzhydryl-amine (519-72-2)

Guidance literature:

With bis(pentafluorophenyl)zinc; In toluene; at 90 ℃; for 1h;

DOI:10.1039/d1cc04137a

upstream raw materials:

diethylamine

Bromodiphenylmethane

diazodiphenylmethane

ethyl bromide

Downstream raw materials:

Diphenylmethane

N,N-diethyl-O-benzhydryl-hydroxylamine

diethyl-benzhydryl-amine oxide

Refernces

• 1、 Tamura, Satoru,Sugawara, Aoi,Sato, Erika,Sato, Fuka,Sato, Keigo,Kawano, Tomikazu. "New approach for induction of alkyl moiety to aliphatic amines by NaBH(OAc)3 with carboxylic acid". supporting information. . Retrieved 2020/04/15.
• 2、 Estiu,Cachau,Castro,Bruno Blanch. "Semiempirical approach to drug design. Antispasmodic activity of benzhydrylamine derivatives". . p. 889 - 900. Retrieved 2007/10/02.