Benzeneacetamide, N-(4-fluorophenyl)-

Base Information

• Chemical Name: Benzeneacetamide, N-(4-fluorophenyl)-
• CAS No.: 5215-28-1
• Molecular Formula: C14H12FNO
• Molecular Weight: 229.254
• Mol file: 5215-28-1.mol

Synonyms:

Chemical Property of Benzeneacetamide, N-(4-fluorophenyl)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetamide, N-(4-fluorophenyl)-

There total 8 articles about Benzeneacetamide, N-(4-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate (260783-80-0) + carbon monoxide (201230-82-2) + 4-fluoroaniline (371-40-4) → 2-(4-fluorophenyl)-N-m-tolylacetamide (5215-28-1)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triphenylphosphine; In dimethyl sulfoxide; toluene; at 100 ℃; for 10h; under 760.051 Torr; Schlenk technique;

DOI:10.1039/c8ob00488a

Reference yield: 83.0%

phenylacetic acid (103-82-2) + 4-fluoroaniline (371-40-4) → 2-(4-fluorophenyl)-N-m-tolylacetamide (5215-28-1)

Guidance literature:

phenylacetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.0833333h; Inert atmosphere;

4-fluoroaniline; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tet.2020.131262

Reference yield: 81.0%

Benzeneacetamide (103-81-1) + 4-fluoroaniline (371-40-4) → 2-(4-fluorophenyl)-N-m-tolylacetamide (5215-28-1)

Guidance literature:

With copper diacetate; In tert-Amyl alcohol; at 140 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201108599

upstream raw materials:

4-fluoroaniline

phenylacetyl chloride

Benzeneacetamide

phenylacetonitrile

Downstream raw materials:

C₁₄H₁₀FN

1-(4-(4-fluorophenylamino)cyclopent-2-enyl)-2-phenylethanone

N-(4-fluorolphenyl)-2-oxo-2-phenylacetamide

Refernces

• 1、 Vasudevan,Routholla, Ganesh,Teja Illa, Giri,Reddy, D. Srinivasa. "Synthesis of α-ketoamides using potassium superoxide (KO2) as an oxidizing agent". . . Retrieved 2020/05/25.
• 2、 Yu, Weijie,Yang, Shuwu,Xiong, Fei,Fan, Tianxiang,Feng, Yan,Huang, Yuanyuan,Fu, Junkai,Wang, Tao. "Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters: Via C-N bond activation". . p. 3099 - 3103. Retrieved 2018/05/22.