Technology Process of 1,5,9-Triazacyclotridecan-2-one, 9-(1-oxo-3-phenylpropyl)-4-phenyl-,
(S)-
There total 27 articles about 1,5,9-Triazacyclotridecan-2-one, 9-(1-oxo-3-phenylpropyl)-4-phenyl-,
(S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 15 steps
1: H2/PdCl2 / methanol / 1 h
2: toluene / 2 h / Heating
3: DMAP / CH2Cl2 / 2 h / Ambient temperature
4: dimethylsulfoxide / 1 h / 90 °C
5: 2N NaOH / ethanol / 3 h / 90 °C
6: 79 percent / 2-chloro-N-methylpyridinium iodide / triethylamine; CH2Cl2 / 1 h / Ambient temperature
7: H2/PdCl2 / methanol / 3 h
8: triethylamine; CH2Cl2 / 1 h / 0 - 25 °C
9: K2CO3 / methanol / 0.5 h / Ambient temperature
10: PCC / CH2Cl2 / 1 h / Ambient temperature
11: CF3CO2H / CH2Cl2 / 0.5 h / Ambient temperature
12: NaBH4 / methanol / 0.67 h / Ambient temperature
13: 94 percent / H2/PdCl2 / 0.67 h
14: 67 percent / 2-chloro-N-methylpyridinium iodide / triethylamine; CH2Cl2 / 1 h / Ambient temperature
15: H2/PtO / methanol / 1 h
With
dmap; sodium hydroxide; sodium tetrahydroborate; platinum(II) oxide; 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; pyridinium chlorochromate; trifluoroacetic acid; palladium dichloride;
In
methanol; ethanol; dichloromethane; dimethyl sulfoxide; triethylamine; toluene;
DOI:10.1016/S0040-4039(01)80739-5
- Guidance literature:
-
Multi-step reaction with 14 steps
1: toluene / 2 h / Heating
2: DMAP / CH2Cl2 / 2 h / Ambient temperature
3: dimethylsulfoxide / 1 h / 90 °C
4: 2N NaOH / ethanol / 3 h / 90 °C
5: 79 percent / 2-chloro-N-methylpyridinium iodide / triethylamine; CH2Cl2 / 1 h / Ambient temperature
6: H2/PdCl2 / methanol / 3 h
7: triethylamine; CH2Cl2 / 1 h / 0 - 25 °C
8: K2CO3 / methanol / 0.5 h / Ambient temperature
9: PCC / CH2Cl2 / 1 h / Ambient temperature
10: CF3CO2H / CH2Cl2 / 0.5 h / Ambient temperature
11: NaBH4 / methanol / 0.67 h / Ambient temperature
12: 94 percent / H2/PdCl2 / 0.67 h
13: 67 percent / 2-chloro-N-methylpyridinium iodide / triethylamine; CH2Cl2 / 1 h / Ambient temperature
14: H2/PtO / methanol / 1 h
With
dmap; sodium hydroxide; sodium tetrahydroborate; platinum(II) oxide; 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; pyridinium chlorochromate; trifluoroacetic acid; palladium dichloride;
In
methanol; ethanol; dichloromethane; dimethyl sulfoxide; triethylamine; toluene;
DOI:10.1016/S0040-4039(01)80739-5
- Guidance literature:
-
Multi-step reaction with 12 steps
1: triethylamine; CH2Cl2 / 1 h / 0 - 25 °C
2: H2/PtO / HCl; ethanol / 3 h
3: 79 percent / 2-chloro-N-methylpyridinium iodide / triethylamine; CH2Cl2 / 1 h / Ambient temperature
4: H2/PdCl2 / methanol / 3 h
5: triethylamine; CH2Cl2 / 1 h / 0 - 25 °C
6: K2CO3 / methanol / 0.5 h / Ambient temperature
7: PCC / CH2Cl2 / 1 h / Ambient temperature
8: CF3CO2H / CH2Cl2 / 0.5 h / Ambient temperature
9: NaBH4 / methanol / 0.67 h / Ambient temperature
10: 94 percent / H2/PdCl2 / 0.67 h
11: 67 percent / 2-chloro-N-methylpyridinium iodide / triethylamine; CH2Cl2 / 1 h / Ambient temperature
12: H2/PtO / methanol / 1 h
With
sodium tetrahydroborate; platinum(II) oxide; 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; pyridinium chlorochromate; trifluoroacetic acid; palladium dichloride;
In
hydrogenchloride; methanol; ethanol; dichloromethane; triethylamine;
DOI:10.1016/S0040-4039(01)80739-5