1-Azetidinesulfonyl chloride, 2-oxo-4-phenyl-

Base Information

• Chemical Name: 1-Azetidinesulfonyl chloride, 2-oxo-4-phenyl-
• CAS No.: 52341-70-5
• Molecular Formula: C9H8ClNO3S
• Molecular Weight: 245.686
• Mol file: 52341-70-5.mol

Synonyms:

Chemical Property of 1-Azetidinesulfonyl chloride, 2-oxo-4-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Azetidinesulfonyl chloride, 2-oxo-4-phenyl-

There total 2 articles about 1-Azetidinesulfonyl chloride, 2-oxo-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + isocyanate de chlorosulfonyle (1189-71-5) → N-chlorosulfonyl-4-phenylazetidin-2-one (52341-70-5)

Guidance literature:

In toluene; at 0 ℃; for 0.333333h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior;

DOI:10.1055/s-0034-1380553

Reference yield:

→ N-chlorosulfonyl-4-phenylazetidin-2-one (52341-70-5)

Guidance literature:

N-Carbonyl-sulfamidsaeurechlorid 1. Styrol, in A., 30-35grad, 1 h 2. 20 min nachruehren;

Reference yield: 100.0%

N-chlorosulfonyl-4-phenylazetidin-2-one (52341-70-5) + 2-methylallyltributyltin (67883-62-9) → 1-(2-methyl-prop-2-ene-1-sulfonyl)-4-phenyl-azetidin-2-one

Guidance literature:

With triethyl borane; oxygen; In hexane; toluene; at 20 ℃;

DOI:10.1021/ol0363725

upstream raw materials:

styrene

isocyanate de chlorosulfonyle

Downstream raw materials:

7-methyl-2,2-dioxo-4-phenyl-2λ⁶-[1,2,3,7]oxathiadiazonan-6-one

methyl β-phenyl-β-methoxy-propionate

3-Methoxy-3-phenyl-propionsaeureamid

β-Amino-hydrozimtsaeureamid-N-sulfonsaeuremethylester

Refernces

• 1、 Shellhamer, Dale F.,Alexander, Kelsey L.,Bunting, Summer A.,Elwin, Sarah L.,Licata, Christine J.,Milligan, Jacob C.,Robinson, Ryan D.,Shipowick, Danielle E.,Smith, Lincoln B.,Perry, Marc C.. "Improved Synthetic Utility of a Sluggish Electrophile: Reaction of Chlorosulfonyl Isocyanate with Unreactive and Reactive Alkenes". supporting information. p. 1944 - 1950. Retrieved 2015/06/30.