N,N-dimethyl-2-(methylamino)acetamide

Base Information

• Chemical Name: N,N-dimethyl-2-(methylamino)acetamide
• CAS No.: 1857-20-1
• Molecular Formula: C5H12N2O
• Molecular Weight: 116.163
• Hs Code.: 2924199090
• European Community (EC) Number: 834-554-7
• DSSTox Substance ID: DTXSID40366314
• Nikkaji Number: J135.655K
• Wikidata: Q82151461
• Mol file: 1857-20-1.mol

Synonyms:N,N-dimethyl-2-(methylamino)acetamide;1857-20-1;N-Me-Gly-NMe;Sar-NMe;sarcosine dimethylamide;N-Methyl-glycine dimethylamide;N1,N1,N2-trimethylglycinamide;MFCD00080937;Sar-NMe2;H-Sar-NMe2;Acetamide, N,N-dimethyl-2-(methylamino)-;N,N,N2-trimethylglycinamide;SCHEMBL729136;N-Me-Gly-NMe2, AldrichCPR;N,N,N~2~-trimethylglycinamide;DTXSID40366314;CAGXPPQTXUCBOY-UHFFFAOYSA-N;HMS1789I01;N,N-dimethyl-2-methylaminoacetamide;methylamino-acetic acid dimethylamide;STK801399;AKOS000200923;BS-12796;SY139333;BB 0262558;FT-0681460;EN300-11144;C77998;ACETAMIDE,N,N-DIMETHYL-2-(METHYLAMINO)-;A880704;AS-787/43399850;N~1~,N~1~,N~2~-trimethylglycinamide hydrochloride;F2158-1034

Chemical Property of N,N-dimethyl-2-(methylamino)acetamide

Chemical Property:

• Vapor Pressure: 1.15mmHg at 25°C
• Refractive Index: 1.437
• Boiling Point: 175.4 °C at 760 mmHg
• PKA: pK1:8.86(+1) (25°C)
• Flash Point: 59.9 °C
• PSA: 32.34000
• Density: 0.934 g/cm³
• LogP: -0.31510
• Storage Temp.: -15°C
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 116.094963011
• Heavy Atom Count: 8
• Complexity: 80.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N-Dimethyl-2-(methylamino)acetamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC(=O)N(C)C
• Uses: N,N-Dimethyl-2-(methylamino)acetamide, HCl

Technology Process of N,N-dimethyl-2-(methylamino)acetamide

There total 7 articles about N,N-dimethyl-2-(methylamino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-bromo-N,N-dimethylethanamide (5468-77-9) + methylamine (74-89-5) → sarcosine dimethylamide (1857-20-1)

Guidance literature:

In tetrahydrofuran; acetonitrile; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2006.10.074

Reference yield:

methylamine (74-89-5) + 2-chloro-N,N-dimethylacetamide (2675-89-0) → sarcosine dimethylamide (1857-20-1)

Guidance literature:

With ethanol;

Reference yield:

Dimethylcarbamoylmethyl-methyl-carbamic acid benzyl ester → sarcosine dimethylamide (1857-20-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h; Ambient temperature;

DOI:10.1021/jm00021a013

upstream raw materials:

sarcosine-N-carboxyanhydride

dimethyl amine

methylamine

2-chloro-N,N-dimethylacetamide

Downstream raw materials:

N,N-dimethyl-2-(N-methylacetamido)acetamide

-sarkosin-dimethylamid

-sarkosyl-sarkosin-dimethylamid

5-[[2-(dimethylamino)-2-oxoethyl](methyl)amino]-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide

Refernces

• 1、 Nikolayevskiy, Herman,Robello, Marco,Scerba, Michael T.,Pasternak, Evan H.,Saha, Mrinmoy,Hartman, Tracy L.,Buchholz, Caitlin A.,Buckheit, Robert W.,Durell, Stewart R.,Appella, Daniel H.. "The structure-activity profile of mercaptobenzamides’ anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target". . p. 818 - 837. Retrieved 2019/06/27.
• 2、 Altamura, Maria,Perrotta, Enzo,Sbraci, Piero,Pestellini, Vittorio,Arcamone, Federico,et al.. "2-Substituted Penems with Amino Acid-Related Side Chains: Synthesis and Antibacterial Activity of a New Series of β-Lactam Antibiotics". . p. 4244 - 4256. Retrieved 2007/10/03.