3,5-BIS(4-CHLOROPHENYL)-4H-1,2,4-TRIAZOL-4-AMINE

Base Information

• Chemical Name: 3,5-BIS(4-CHLOROPHENYL)-4H-1,2,4-TRIAZOL-4-AMINE
• CAS No.: 52868-19-6
• Molecular Formula: C14H10Cl2N4
• Molecular Weight: 305.166
• Mol file: 52868-19-6.mol

Synonyms:3,5-bis(4-chlorophenyl)-4-amino-1,2,4-triazole;3,5-bis-(4-chloro-phenyl)-[1,2,4]triazol-4-ylamine;1-Amino-2,5-bis-(4-chlorphenyl)-1,3,4-triazol;3,5-bis-(4-chlorophenyl)-4-amino-1,2,4-triazole;

Chemical Property of 3,5-BIS(4-CHLOROPHENYL)-4H-1,2,4-TRIAZOL-4-AMINE

Chemical Property:

• Melting Point: 289 °C
• PSA: 56.73000
• LogP: 4.21390

Purity/Quality:

3,5-Bis(4-chlorophenyl)-4H-1,2,4-triazol-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-BIS(4-CHLOROPHENYL)-4H-1,2,4-TRIAZOL-4-AMINE

There total 5 articles about 3,5-BIS(4-CHLOROPHENYL)-4H-1,2,4-TRIAZOL-4-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-Cyanochlorobenzene (623-03-0) → 3-(4'-chlorophenyl)-5-(4'-chlorophenyl)-4-amino-1,2,4-triazole (52868-19-6)

Guidance literature:

With hydrazine dihydrochloride; hydrazine hydrate; In ethylene glycol; at 130 ℃;

DOI:10.1002/jhet.5570360123

Reference yield: 90.0%

4-chlorobenzoic acid hydrazide (536-40-3) → 3-(4'-chlorophenyl)-5-(4'-chlorophenyl)-4-amino-1,2,4-triazole (52868-19-6)

Guidance literature:

With hydrazine; at 250 ℃; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.03.007

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 3-(4'-chlorophenyl)-5-(4'-chlorophenyl)-4-amino-1,2,4-triazole (52868-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / hydroxylamine hydrochloride; N-methyl-2-pyrrolidinone / 0.08 h / 200 °C / microwave irradiation

2: hydrazine dihydrochloride; hydrazine monohydrate / ethane-1,2-diol / 0.1 h / 160 °C / microwave irradiation

With 1-methyl-pyrrolidin-2-one; hydrazine dihydrochloride; hydroxylamine hydrochloride; hydrazine hydrate; In ethylene glycol;

DOI:10.3987/COM-02-9584

upstream raw materials:

4-Cyanochlorobenzene

4-chlorobenzaldehyde

para-chlorobenzoic acid

4-chlorobenzoic acid hydrazide

Downstream raw materials:

2-{[3-(3,5-bis(3,5-dinitrophenyl)-1H-1,2,4-triazol-1-yl)propyl]sulfanyl}-1,3-benzothiazole

3,5-bis(4-chlorophenyl)-4H-1,2,4-triazole

Refernces

• 1、 Azam, Mohammed Afzal,Suresh, Bhojraj,Srinivas, Naga,Sachdev, Sumit,Rajeshkumar, Raman. "Synthesis and biological evaluation of some novel 3,5-disubstituted-1,2,4- triazole incorporated 2-mercaptobenzothiazoles". . p. 739 - 748. Retrieved 2013/02/22.
• 2、 Koshima, Hideko,Hamada, Mitsuo,Tani, Makiko,Iwasaki, Shunsuke,Sato, Fumika. "High-throughput synthesis of symmetrically 3,5-disubstituted 4-amino-1,2,4-triazoles from aldehydes using microwave". . p. 2145 - 2148. Retrieved 2007/10/03.