4-Fluoro-3-nitrotoluene

Base Information

• Chemical Name: 4-Fluoro-3-nitrotoluene
• CAS No.: 446-11-7
• Molecular Formula: C7H6FNO2
• Molecular Weight: 155.129
• Hs Code.: 2904909090
• Mol file: 446-11-7.mol

Synonyms:3-Nitro-4-fluorotoluene;

Chemical Property of 4-Fluoro-3-nitrotoluene

Chemical Property:

• Appearance/Colour: crystalline
• Vapor Pressure: 0.0612mmHg at 25°C
• Melting Point: 28 °C
• Refractive Index: 1.524
• Boiling Point: 239.7 °C at 760 mmHg
• Flash Point: 98.7 °C
• PSA: 45.82000
• Density: 1.274 g/cm³
• LogP: 2.56550
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-3-nitrotoluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C
• Statements: 20/21/22-36/37/38-34
• Safety Statements: 26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-3-nitrotoluene

There total 10 articles about 4-Fluoro-3-nitrotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-fluorotoluene (352-32-9) → 2,6-dinitro-p-cresol (609-93-8) + 4-fluoro-3-nitrotoluene (446-11-7)

Guidance literature:

With nitric acid;

Reference yield:

tetrachloromethane (56-23-5) + p-fluorotoluene (352-32-9) + nitric acid (7697-37-2,78989-43-2) → 4-methyl-2-nitrophenol (119-33-5) + 2-nitro-4-fluorotoluene (446-10-6) + 2,6-dinitro-p-cresol (609-93-8) + 4-fluoro-3-nitrotoluene (446-11-7)

Guidance literature:

at -5 ℃;

Reference yield:

p-fluorotoluene (352-32-9) → 2-nitro-4-fluorotoluene (446-10-6) + 4-fluoro-3-nitrotoluene (446-11-7)

Guidance literature:

With isopentyl nitrate; trifluorormethanesulfonic acid; 1-ethyl-3-methylimidazolium triflate; at 0 ℃; Title compound not separated from byproducts.;

DOI:10.1021/jo000523p

upstream raw materials:

p-fluorotoluene

4-methyl-2-nitrobenzenediazonium

tetrachloromethane

nitric acid

Downstream raw materials:

N-(4-methyl-2-nitrophenyl)piperidine-2-carboxylic acid

C₁₈H₁₆N₂O₅

tert-butyl 4-((4-methyl-2-nitrophenyl)amino)piperidine-1-carboxylate

tert-butyl 3-hydroxy-2-(4-methyl-2-nitrophenyl)but-2-enoate

Refernces

• 1、 Laali,Gettwert. "Electrophilic nitration of aromatics in ionic liquid solvents". . p. 35 - 40. Retrieved 2007/10/03.