N-(2-Hydroxyphenyl)benzamide

Base Information

• Chemical Name: N-(2-Hydroxyphenyl)benzamide
• CAS No.: 3743-70-2
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Hs Code.: 2924299090
• NSC Number: 28477
• DSSTox Substance ID: DTXSID10282855
• Nikkaji Number: J861.743K
• Wikidata: Q82017231
• ChEMBL ID: CHEMBL229357
• Mol file: 3743-70-2.mol

Synonyms:N-(2-Hydroxyphenyl)benzamide;3743-70-2;CHEMBL229357;Benzamide, N-(2-hydroxyphenyl)-;o-Benzamidophenol;N-(2-Hydroxy-phenyl)-benzamide;2-Benzamidophenol;NSC28477;2'-Hydroxybenzanilide;2-(Benzoylamino)phenol;Enamine_000131;Benzanilide, 2'-hydroxy-;N-Benzoyl-2-hydroxyaniline;Oprea1_107296;Oprea1_541127;N-(2-hydroxyphenyl)-benzamide;(hydroxybenzylideneamino)-phenol;SCHEMBL1470784;Phenyl(2-Hydroxyphenyl)Carbamate;DTXSID10282855;HMS1394F21;BDBM50399198;NSC 28477;NSC-28477;STK089193;AKOS000491604;CS-0354157;SR-01000395729;SR-01000395729-1;Z56764779

Chemical Property of N-(2-Hydroxyphenyl)benzamide

Chemical Property:

• Vapor Pressure: 0.00257mmHg at 25°C
• Boiling Point: 278.1°Cat760mmHg
• Flash Point: 122°C
• PSA: 49.33000
• Density: 1.278g/cm³
• LogP: 2.71750
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 213.078978594
• Heavy Atom Count: 16
• Complexity: 236

Purity/Quality:

99%min ^*data from raw suppliers

N-(2-Hydroxyphenyl)benzamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)NC2=CC=CC=C2O

Technology Process of N-(2-Hydroxyphenyl)benzamide

There total 91 articles about N-(2-Hydroxyphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

N-(2-bromophenyl)benzamide (70787-27-8) → 2-phenylbenzo[d]oxazole (833-50-1) + N-(2-hydroxyphenyl)benzamide (3743-70-2)

Guidance literature:

With copper(II) oxide; water; caesium carbonate; at 100 ℃; for 22h; Green chemistry;

DOI:10.1039/c3ra46820h

Reference yield: 47.0%

2-amino-phenol (95-55-6) → 2-phenylbenzo[d]oxazole (833-50-1) + N-(2-hydroxyphenyl)benzamide (3743-70-2)

Guidance literature:

2-amino-phenol; With diethylaluminium chloride; In toluene; at 0 - 20 ℃;

hydroxymethyl JandaJel^TM resin-bound benzoyl ester; In toluene; for 24h; Heating;

DOI:10.1016/j.tetlet.2003.10.168

Reference yield: 8.0%

benzoic acid anhydride (93-97-0) + 2-amino-phenol (95-55-6) → 2-phenylbenzo[d]oxazole (833-50-1) + N-(2-hydroxyphenyl)benzamide (3743-70-2)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; water; at 445 ℃; for 0.00277778h; under 300030 Torr; Solvent; Temperature; Pressure; Supercritical conditions;

upstream raw materials:

2-phenylbenzo[d]oxazole

ethanol

sodium acetate

benzoic acid-(2-amino-phenyl ester); hydrochloride

Downstream raw materials:

1-benzoylamino-2-[1]naphthoyloxy-benzene

1-acetylamino-2-benzoyloxy-benzene

2-benzamidophenyl acetate

1-benzoyloxy-2-diacetylamino-benzene

Refernces

• 1、 Boughaba, Sara,Aouf, Zineb,Zerrouki, Rachida,Aouf, Nour Eddine. "N,O-Benzyl Protection of Structurally Varied Amines and Phenols Using Wells-Dawson Heteropolyacid Catalyst". . p. 301 - 310. Retrieved 2021/05/24.
• 2、 Yadav, Lalit,Tiwari, Mohit K.,Shyamlal, Bharti Rajesh Kumar,Chaudhary, Sandeep. "Organocatalyst in Direct C(sp2)-H Arylation of Unactivated Arenes: [1-(2-Hydroxyethyl)-piperazine]-Catalyzed Inter-/Intra-molecular C-H Bond Activation". . p. 8121 - 8141. Retrieved 2020/07/16.