3,3,3-Trifluoro-1-propanol

Base Information

• Chemical Name: 3,3,3-Trifluoro-1-propanol
• CAS No.: 2240-88-2
• Molecular Formula: C3H5F3O
• Molecular Weight: 114.067
• Hs Code.: 29055900
• Mol file: 2240-88-2.mol

Synonyms:2-(Trifluoromethyl)ethanol;

Chemical Property of 3,3,3-Trifluoro-1-propanol

Chemical Property:

• Vapor Pressure: 2830mmHg at 25°C
• Refractive Index: 1.32
• Boiling Point: 86.5 ºC at 760 mmHg
• PKA: 14.09±0.10(Predicted)
• Flash Point: 47.1 ºC
• PSA: 20.23000
• Density: 1.24 g/cm³
• LogP: 0.93110
• Storage Temp.: 2-8°C
• Water Solubility.: Fully miscible in water.

Purity/Quality:

99% ^*data from raw suppliers

3,3,3-Trifluoro-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F
• Hazard Codes: F,T
• Statements: 20/21/22-36/37/38-36-25-10
• Safety Statements: 26-36/37/39-45-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,3,3-Trifluoro-1-propanol is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.

Technology Process of 3,3,3-Trifluoro-1-propanol

There total 14 articles about 3,3,3-Trifluoro-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-acetoxy-3,3,3-trifluoropropane (407-63-6) → 3,3,3-Trifluoropropanol (2240-88-2)

Guidance literature:

With potassium hydroxide; benzyl tri-n-butylammonium bromide; at 75 - 80 ℃; for 0.333333h;

DOI:10.1016/S0022-1139(00)80885-4

Reference yield: 95.0%

2-bromo-3,3,3-trifluoropropan-1-ol (311-86-4) → 3,3,3-Trifluoropropanol (2240-88-2)

Guidance literature:

With hydrogen; potassium carbonate; In methanol; at 80 ℃; for 3h; under 37503.8 Torr; Reagent/catalyst; Pressure; Temperature; Autoclave;

Reference yield: 91.1%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,1,1-trifluoro-2-chloroethane (75-88-7) + C2H2ClF3Mg + C3H4F3O(1-)*Cl(1-)*Mg(2+) → 3,3,3-Trifluoropropanol (2240-88-2)

Guidance literature:

1,1,1-trifluoro-2-chloroethane; With ethyl bromide; magnesium; In tetrahydrofuran; toluene; at 20 ℃; for 2h; Inert atmosphere;

formaldehyd; C₂H₂ClF₃Mg; In tetrahydrofuran; toluene; at 40 ℃; for 2h; under 375.038 Torr; Inert atmosphere;

C₃H₄F₃O^(1-)*Cl^(1-)*Mg⁽²⁺⁾; With hydrogenchloride; In tetrahydrofuran; water; toluene; for 1.5h; Reagent/catalyst; Temperature; Pressure; Inert atmosphere;

upstream raw materials:

oxirane

(trifluoro methyl) magnesiumiodide

3-chloro-1,1,1-trifluoropropane

1-acetoxy-3,3,3-trifluoropropane

Downstream raw materials:

3,3,3-trifluoropropanal

3,3,3-Trifluoropropionic acid

methyl (2s,3aR,5r,6aS)-5-cyano-5-[4-methoxy-3-(3,3,3-trifluoropropoxy)phenyl]octahydropentalene-2-carboxylate

4-methyl-2-{6-(3,3,3-trifluoropropoxy)-2-[4-(4-trifluoromethoxyphenyl) imidazol-1-yl] pyrimidin-4-ylamino} pentanoic acid (3-ethoxypropyl)amide

Refernces

• 1、 Polishchuk,V.R. et al.. "-". . . Retrieved 1971.
• 2、 -. "Preparation method of 3, 3, 3-trifluoropropanol". Paragraph 0040-0093; 0113. . Retrieved 2021/11/19.
• 3、 -. "Method for preparing 3,3,3-trifluoro propanol". Paragraph 0022; 0023. . Retrieved 2016/12/01.