Cyclopropanecarboxylic acid, 2,2-diphenyl-, (S)-

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 2,2-diphenyl-, (S)-
• CAS No.: 53692-73-2
• Molecular Formula: C16H14O2
• Molecular Weight: 238.286
• Mol file: 53692-73-2.mol

Synonyms:

Chemical Property of Cyclopropanecarboxylic acid, 2,2-diphenyl-, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 2,2-diphenyl-, (S)-

There total 7 articles about Cyclopropanecarboxylic acid, 2,2-diphenyl-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl (1S)-2,2-diphenylcyclopropylcarboxylate (67428-04-0) → (1S)-2,2-diphenylcyclopropane carboxylic acid (53692-73-2)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 12h;

DOI:10.1002/chem.200305045

Reference yield: 77.0%

2,2-diphenyl-cyclopropanecarboxylic acid (7150-12-1) → (1S)-2,2-diphenylcyclopropane carboxylic acid (53692-73-2)

Guidance literature:

racemate seperation with brycine dihydrate;

DOI:10.1007/BF00809355

Reference yield: 22.0%

C16H14O2*C23H26N2O4 (1333307-70-2) → (1S)-2,2-diphenylcyclopropane carboxylic acid (53692-73-2)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1002/hlca.201100135

upstream raw materials:

2,2-diphenyl-cyclopropanecarboxylic acid

ethyl (1S)-2,2-diphenylcyclopropylcarboxylate

1,1-Diphenylethylene

methyl 2,2-diphenylcyclopropane-1-carboxylate

Downstream raw materials:

C₁₆H₁₄O₂*C₂₃H₂₆N₂O₄

(S)-2,2-diphenyl-cyclopropanecarbonitrile

ethyl (1S)-2,2-diphenylcyclopropylcarboxylate

Refernces

• 1、 Berkessel, Albrecht,Kaiser, Patrick,Lex, Johann. "Electronically tuned chiral ruthenium porphyrins: Extremely stable and selective catalysts for asymmetric epoxidation and cyclopropanation". . p. 4746 - 4756. Retrieved 2007/10/03.
• 2、 Brunner, Henri,Miehling, Wolfgang. "Enantioselective Cyclopropanation of 1,1-Diphenylethylene and Diazoacetic Acid Ester with Copper Catalysts". . p. 1237 - 1254. Retrieved 2007/10/02.