2-Ethyl-1,3-dioxolane-4-methanol

Base Information

• Chemical Name: 2-Ethyl-1,3-dioxolane-4-methanol
• CAS No.: 53951-44-3
• Molecular Formula: C6H12O3
• Molecular Weight: 132.159
• Hs Code.: 2932999099
• Mol file: 53951-44-3.mol

Synonyms:4-hydroxymethyl-2-ethyl-1,3-dioxolane;2-ethyl-1,3-dioxolane-4-methanol;1,3-Dioxolane-4-methanol,2-ethyl;(2-ethyl-[1,3]dioxolan-4-yl)-methanol;(2-Aethyl-[1,3]dioxolan-4-yl)-methanol;1,3-Dioxolane-4-methanol, 2-ethyl-;

Chemical Property of 2-Ethyl-1,3-dioxolane-4-methanol

Chemical Property:

• Vapor Pressure: 0.0909mmHg at 25°C
• Boiling Point: 198.4oC at 760 mmHg
• Flash Point: 90.4oC
• PSA: 38.69000
• Density: 1.041g/cm3
• LogP: 0.13020

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Ethyl-1,3-dioxolane-4-methanol is a useful reagent in the selective ruthenium-mediated synthesis of mixed acetals and orthoesters by addtion of alcohol and phenols to allyl ethers.

Technology Process of 2-Ethyl-1,3-dioxolane-4-methanol

There total 6 articles about 2-Ethyl-1,3-dioxolane-4-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propionaldehyde (123-38-6) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 4-hydroxymethyl-2-ethyl-1,3-dioxolane (53951-44-3) + 2-ethyl-5-hydroxy-1,3-dioxane

Guidance literature:

With WO_x-promoted TiO₂-ZrO₂ solid acid catalyst; In neat (no solvent); at 44.84 ℃; for 2h;

DOI:10.1007/s10562-021-03733-2

Reference yield:

3-allyloxy-1,2-propanediol (123-34-2) → 4-hydroxymethyl-2-ethyl-1,3-dioxolane (53951-44-3) + 2-ethyl-5-hydroxy-1,3-dioxane

Guidance literature:

tris(triphenylphosphine)ruthenium(II) chloride; at 120 ℃; for 1h;

DOI:10.1055/s-2004-825597

Reference yield:

propionaldehyde (123-38-6) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 4-hydroxymethyl-2-ethyl-1,3-dioxolane (53951-44-3) + trans-2-ethyl-[1,3]dioxan-5-ol (66943-94-0) + cis-2-ethyl-[1,3]dioxan-5-ol (66943-93-9)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Title compound not separated from byproducts; Heating;

upstream raw materials:

4-nitro-benzoyl chloride

propionaldehyde

glycerol

3-allyloxy-1,2-propanediol

Downstream raw materials:

propionaldehyde

glycerol

Refernces

• 1、 Baithy, Mallesham,Mukherjee, Deboshree,Rangaswamy, Agolu,Reddy, Benjaram M.. "Structure–Activity Relationships of WOx-Promoted TiO2–ZrO2 Solid Acid Catalyst for Acetalization and Ketalization of Glycerol towards Biofuel Additives". . . Retrieved 2021/07/25.
• 2、 Urbala, Magdalena,Ku?nik, Nikodem,Krompiec, Stanis?aw,Rzepa, Józef. "Highly selective isomerization of allyloxyalcohols to cyclic acetals or 1-propenyloxyalcohols". . p. 1203 - 1206. Retrieved 2007/10/03.