2-bromo-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid

Base Information

• Chemical Name: 2-bromo-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid
• CAS No.: 30007-57-9
• Molecular Formula: C11H8 Br N O4
• Molecular Weight: 298.093
• Mol file: 30007-57-9.mol

Synonyms:2-Isoindolinepropionicacid, a-bromo-1,3-dioxo- (8CI); b-Alanine, a-bromo-N-phthalyl- (1CI); NSC244270

Chemical Property of 2-bromo-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid

Chemical Property:

• Vapor Pressure: 1.02E-08mmHg at 25°C
• Boiling Point: 445.4°C at 760 mmHg
• Flash Point: 223.2°C
• Density: 1.808g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid

There total 1 articles about 2-bromo-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → 2-bromo-3-phthalimido-propionic acid (30007-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 160 °C

2: Br₂, P red / Heating

With phosphorus; bromine;

DOI:10.1007/BF00474362

Reference yield:

2-bromo-3-phthalimido-propionic acid (30007-57-9) → 2-((1,3-dioxoisoindolin-2-yl)methyl)-5-(2-oxocyclohexyl)pentanoic acid

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 0.5 h / 40 °C / Inert atmosphere

1.2: 6 h / pH 4 - 5 / Inert atmosphere

2.1: dilauryl peroxide / neat (no solvent) / 85 °C / Sealed tube

3.1: triethylamine; 2,2'-azobis(isobutyronitrile); hypophosphorous acid / water; 1,4-dioxane / Reflux

With 2,2'-azobis(isobutyronitrile); dilauryl peroxide; hypophosphorous acid; triethylamine; sodium hydroxide; In 1,4-dioxane; water;

DOI:10.1021/acs.orglett.0c01087

Reference yield:

2-bromo-3-phthalimido-propionic acid (30007-57-9) → C23H27NO6S2

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 0.5 h / 40 °C / Inert atmosphere

1.2: 6 h / pH 4 - 5 / Inert atmosphere

2.1: dilauryl peroxide / neat (no solvent) / 85 °C / Sealed tube

With dilauryl peroxide; sodium hydroxide; In water;

DOI:10.1021/acs.orglett.0c01087

upstream raw materials:

phthalic anhydride

Downstream raw materials:

methyl (E)-4-(1,3-dioxoisoindolin-2-yl)but-2-enoate

4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-butyric acid methyl ester

Refernces

• 1、 Golubev, A. A.,Semenenko, M. N.,Mandrugin, A. A.,Fedoseev, V. M.. "FORMATION OF DERIVATIVES OF THIAZOLINE BY THE REACTION OF THIOUREA WITH 2-BROMO-3-AMINOPROPIONIC ACID". . p. 1367 - 1369. Retrieved 2007/10/02.