N-Propylcyclohexanamine

Base Information

• Chemical Name: N-Propylcyclohexanamine
• CAS No.: 3592-81-2
• Molecular Formula: C9H19N
• Molecular Weight: 141.257
• Hs Code.: 2921300090
• DSSTox Substance ID: DTXSID60189486
• Nikkaji Number: J485.053J
• Wikidata: Q83061592
• Mol file: 3592-81-2.mol

Synonyms:N-PROPYLCYCLOHEXANAMINE;3592-81-2;N-CYCLOHEXYL-N-PROPYLAMINE;Cyclohexanamine, N-propyl-;Cyclohexylaminopropan;cyclohexyl-1-propylamine;cyclohexyl-n-propyl-amine;N-(n-propyl)cyclohexanamine;SCHEMBL26069;DTXSID60189486;N-propylcyclohexanamine, AldrichCPR;MFCD03210942;STK125264;AKOS000168601;BS-37866;BB 0254268;EN300-32236

Chemical Property of N-Propylcyclohexanamine

Chemical Property:

• Vapor Pressure: 0.517mmHg at 25°C
• Boiling Point: 191.3°Cat760mmHg
• Flash Point: 59.5°C
• PSA: 12.03000
• Density: 0.84g/cm³
• LogP: 2.70960
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 141.151749610
• Heavy Atom Count: 10
• Complexity: 74.8

Purity/Quality:

98%min ^*data from raw suppliers

N-Propylcyclohexanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCNC1CCCCC1

Technology Process of N-Propylcyclohexanamine

There total 21 articles about N-Propylcyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-Allylcyclohexylamin (6628-00-8) → N-propylcyclohexylamine (3592-81-2)

Guidance literature:

With 4,4'-di-tert-butylbiphenyl; lithium; isopropyl alcohol; nickel dichloride; In tetrahydrofuran; at 20 - 76 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2009.10.057

Reference yield: 93.0%

propylamine (107-10-8,42939-71-9) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → N-propylcyclohexylamine (3592-81-2)

Guidance literature:

With triethylsilane; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/aoc.3090

Reference yield: 79.0%

N-(cyclohexylidene)-1-propanamine (22668-89-9) → N-propylcyclohexylamine (3592-81-2)

Guidance literature:

With triethylsilane; palladium diacetate; In ethanol; for 0.5h; Inert atmosphere;

DOI:10.1002/aoc.2961

upstream raw materials:

cyclohexanone

propiononitrile

propan-1-ol

cyclohexylamine

Downstream raw materials:

2,6-Dibromo-4-[(cyclohexyl-propyl-amino)-methyl]-phenol

N-Isopropoxycarbonyl-3-(N-cyclohexyl-N-propylcarbamoyloxy)anilin

N-Cyclohexyl-4-(2-oxo-1,2-dihydro-quinolin-6-yloxy)-N-propyl-butyramide

N-cyclohexylpropionaldimine

Refernces

• 1、 Zhang, Sishi,Xu, Jie,Cheng, Hongmei,Zang, Cuicui,Sun, Bin,Jiang, Heyan,Bian, Fengxia. "Highly efficient one-pot multi-directional selective hydrogenation and N-alkylation catalyzed by Ru/LDH under mild conditions". supporting information. . Retrieved 2020/03/30.
• 2、 Matzel, Philipp,Krautschick, Lukas,H?hne, Matthias. "Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae". . p. 2022 - 2027. Retrieved 2017/10/07.