Ethane, 1-bromo-2-(methylthio)-

Base Information

• Chemical Name: Ethane, 1-bromo-2-(methylthio)-
• CAS No.: 54187-93-8
• Molecular Formula: C3H7BrS
• Molecular Weight: 155.059
• Mol file: 54187-93-8.mol

Synonyms:(2-Brom-aethyl)-methyl-sulfid;(2-bromo-ethyl)-methyl sulfide;2-(methylthio)ethyl bromide;(2-bromoethyl)(methyl)sulfane;1-Brom-2-methylmercapto-aethan;Ethane,1-bromo-2-(methylthio);1-Bromo-2-(methylsulfanyl)ethane;1-bromo-2-methylthioethane;

Chemical Property of Ethane, 1-bromo-2-(methylthio)-

Chemical Property:

• Boiling Point: 57-58 °C(Press: 18 Torr)
• PSA: 25.30000
• Density: 1.473±0.06 g/cm3(Predicted)
• LogP: 1.74430

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-2-methylsulfanylethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Bromo-2-methylsulfanylethane is used as a reactant in the preparation of pantolactams as androgen receptor antagonists.

Technology Process of Ethane, 1-bromo-2-(methylthio)-

There total 4 articles about Ethane, 1-bromo-2-(methylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-methylmercapto-ethanol (5271-38-5) → 1-bromo-2-(methylsulphanyl)ethane (54187-93-8)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 0 - 5 ℃; for 1h;

Reference yield:

methylthiol (74-93-1) + ethylene dibromide (106-93-4) → 1-bromo-2-(methylsulphanyl)ethane (54187-93-8)

Guidance literature:

methylthiol; With sodium ethanolate; In ethanol; at 20 ℃; for 0.5h;

ethylene dibromide; In ethanol; at 0 - 20 ℃; for 1h;

DOI:10.1039/c6gc03187k

Reference yield:

methylthiol (74-93-1) → 1-bromo-2-(methylsulphanyl)ethane (54187-93-8)

Guidance literature:

With tetrachloromethane; bromine; Einleiten von Aethylen in das Reaktionsgemisch;

upstream raw materials:

methylthiol

2-methylmercapto-ethanol

ethylene dibromide

Downstream raw materials:

1-bromo-2-(methylsulfonyl)ethane

2-(methylthio)-N-(2-morpholinoethyl)ethanamine

2-(o-Formyl-phenoxy)-aethyl-methylsulfid

2-hydroxyethyl methyl sulfoxide

Refernces

• 1、 Matsuura et al.. "". . p. 344,345, 347, 349. Retrieved 1979.
• 2、 Hock, Katharina J.,Mertens, Lucas,Metze, Friederike K.,Schmittmann, Clemens,Koenigs, Rene M.. "Difluoro- and trifluoro diazoalkanes-complementary approaches in batch and flow and their application in cycloaddition reactions". supporting information. p. 905 - 909. Retrieved 2017/08/14.