2-(Ethylamino)acetic acid hydrochloride

Base Information

• Chemical Name: 2-(Ethylamino)acetic acid hydrochloride
• CAS No.: 542-53-0
• Molecular Formula: C4H9NO2.ClH
• Molecular Weight: 139.582
• Hs Code.: 2922499990
• European Community (EC) Number: 819-297-0
• DSSTox Substance ID: DTXSID30597377
• Mol file: 542-53-0.mol

Synonyms:2-(ethylamino)acetic acid hydrochloride;542-53-0;Ethylglycocoll hydrochloride;ethyl glycine hydrochloride;2-(ethylamino)acetic acid;hydrochloride;ethyl glycine.HCl;N-Ethyl-glycine HCl;ethylglycinate hydrochloride;ethyl glycine monohydrochloride;SCHEMBL272523;DTXSID30597377;GIUTUZDGHNZVIA-UHFFFAOYSA-N;2-(ethylamino)aceticacidhydrochloride;AKOS008104959;N-Ethylglycine--hydrogen chloride (1/1);CS-0250575;EN300-51424;F79581;Z744593094

Chemical Property of 2-(Ethylamino)acetic acid hydrochloride

Chemical Property:

• Melting Point: 179-180 °C
• PSA: 49.33000
• LogP: 0.87340
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 139.0400063
• Heavy Atom Count: 8
• Complexity: 62.7

Purity/Quality:

98%min ^*data from raw suppliers

N-Ethyl-glycineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNCC(=O)O.Cl

Technology Process of 2-(Ethylamino)acetic acid hydrochloride

There total 2 articles about 2-(Ethylamino)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethanol (64-17-5) + 2-aminoethanoic acid hydrochloride (6000-43-7) → N-ethyl glycine hydrochloride (542-53-0)

Guidance literature:

With thionyl chloride; at -20 ℃; for 2h; Inert atmosphere; Reflux;

DOI:10.1021/ic502963n

Reference yield: 59.5%

ethylamine (75-04-7,85404-22-4) + Glyoxilic acid (298-12-4) → N-ethyl glycine hydrochloride (542-53-0)

Guidance literature:

ethylamine; Glyoxilic acid; In water; at 25 ℃; for 24h;

With hydrogenchloride; In water; for 12h; Reflux;

DOI:10.1002/pola.28402

Reference yield: 98.0%

N-ethyl glycine hydrochloride (542-53-0) + 2-(1-methyl-4-piperidinyl)aminobenzophenone imine (96110-83-7) → ethyl 2-[[[2-(1-methyl-4-piperidinyl)aminophenyl](phenyl)methylen]amino]acetate (96110-99-5)

Guidance literature:

With acetic acid; In ethanol;

upstream raw materials:

ethylamine

Glyoxilic acid

ethanol

2-aminoethanoic acid hydrochloride

Downstream raw materials:

N-(Diphenyl-acetyl)-N-ethyl-glycin

N-Ethyl-N-(2-Methyl-4-chlor-phenoxyacetyl)-glycin

N-Benzoyl-N-ethyl-glycin

N-(2,4-Dichlor-phenoxyacetyl)-N-ethyl-glycin

Refernces

• 1、 Albertin, Gabriele,Antoniutti, Stefano,Botter, Alessandra,Castro, Jesús. "Hydrolysis of coordinated diazoalkanes to yield side-on 1,2-diazene derivatives". supporting information. p. 2091 - 2093. Retrieved 2015/03/18.