2-IODO-ISONICOTINIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-IODO-ISONICOTINIC ACID METHYL ESTER
• CAS No.: 134579-47-8
• Molecular Formula: C₇H₆INO₂
• Molecular Weight: 263.035
• Hs Code.: 2933399090
• Mol file: 134579-47-8.mol

Synonyms:4-Pyridinecarboxylic acid, 2-iodo-, methyl ester;

Chemical Property of 2-IODO-ISONICOTINIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000812mmHg at 25°C
• Refractive Index: 1.603
• Boiling Point: 305.6 °C at 760 mmHg
• Flash Point: 138.6 °C
• PSA: 39.19000
• Density: 1.844 g/cm³
• LogP: 1.47280
• Storage Temp.: Refrigerated.

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl2-iodoisonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-IODO-ISONICOTINIC ACID METHYL ESTER

There total 2 articles about 2-IODO-ISONICOTINIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

2-chloroisonicotinic acid, (6313-54-8) → methyl 2-iodoisonicotinate (134579-47-8) + 2-iodopyridine-4-carboxylic acid (58481-10-0)

Guidance literature:

With sodium iodide; In butanone;

Reference yield: 88.0%

methanol (67-56-1) + 2-iodopyridine-4-carboxylic acid (58481-10-0) → methyl 2-iodoisonicotinate (134579-47-8)

Guidance literature:

With sulfuric acid; for 16h; Reflux;

DOI:10.1021/ol501967c

Reference yield: 59.0%

methyl 2-iodoisonicotinate (134579-47-8) + (trifluoromethyl)trimethylsilane (81290-20-2) → 2-trifluoromethyl-isonicotinic acid methyl ester (588702-68-5)

Guidance literature:

With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; Trimethyl borate; In dimethyl sulfoxide; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol501967c

upstream raw materials:

methanol

2-iodopyridine-4-carboxylic acid

2-chloroisonicotinic acid,

Downstream raw materials:

2-trifluoromethyl-isonicotinic acid methyl ester

Refernces

• 1、 -. "Aryl-4-ethynyl-isoxazole derivatives". Page/Page column 9. . Retrieved 2008/06/13.