1-(2-Furyl)-3-(2-thienyl)-2-propen-1-one

Base Information

• Chemical Name: 1-(2-Furyl)-3-(2-thienyl)-2-propen-1-one
• CAS No.: 13343-95-8
• Molecular Formula: C11H8 O2 S
• Molecular Weight: 204.249
• European Community (EC) Number: 236-391-1
• Nikkaji Number: J424.446J,J213.857C
• ChEMBL ID: CHEMBL1895607
• Mol file: 13343-95-8.mol

Synonyms:1-(2-Furyl)-3-(2-thienyl)-2-propen-1-one;13343-95-8;(E)-1-(furan-2-yl)-3-thiophen-2-ylprop-2-en-1-one;EINECS 236-391-1;2-Propen-1-one, 1-(2-furanyl)-3-(2-thienyl)-;1-(Furan-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one;C11H8O2S;MLS001178859;SCHEMBL3593220;CHEMBL1895607;HIBLXINPOYYHFI-AATRIKPKSA-N;MFCD00016897;AKOS022192338;SMR000477543;1-(2-Furyl)-3-(2-thienyl)-2-propene-1-one;AO-476/42431059;(E)-1-(2-Furanyl)-3-(2-thienyl)-2-propen-1-one;(2E)-1-(2-Furyl)-3-(2-thienyl)-2-propen-1-one #;Z445129226;(2E)-1-(FURAN-2-YL)-3-(THIOPHEN-2-YL)PROP-2-EN-1-ONE

Chemical Property of 1-(2-Furyl)-3-(2-thienyl)-2-propen-1-one

Chemical Property:

• Vapor Pressure: 0.000136mmHg at 25°C
• Boiling Point: 333.5°C at 760 mmHg
• Flash Point: 155.5°C
• PSA: 58.45000
• Density: 1.26g/cm³
• LogP: 3.23720
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 204.02450067
• Heavy Atom Count: 14
• Complexity: 237

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-FURYL)-3-(2-THIENYL)-2-PROPEN-1-ONE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=COC(=C1)C(=O)C=CC2=CC=CS2
• Isomeric SMILES: C1=COC(=C1)C(=O)/C=C/C2=CC=CS2

Technology Process of 1-(2-Furyl)-3-(2-thienyl)-2-propen-1-one

There total 2 articles about 1-(2-Furyl)-3-(2-thienyl)-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

thiophene-2-carbaldehyde (98-03-3) + 1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) → 1-(furan-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one (13343-95-8)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃; for 5h; Temperature;

DOI:10.1016/j.bioorg.2019.103516

Reference yield:

→ 1-(furan-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one (13343-95-8)

Guidance literature:

Reference yield: 86.0%

1-(furan-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one (13343-95-8) + phenylhydrazine (100-63-0) → 3-furan-2-yl-1-phenyl-5-thiophen-2-yl-4,5-dihydro-1H-pyrazole (20264-78-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1021/je00036a038

upstream raw materials:

thiophene-2-carbaldehyde

1-(2-furyl)-1-ethanone

Downstream raw materials:

3-furan-2-yl-1-phenyl-5-thiophen-2-yl-4,5-dihydro-1H-pyrazole

Refernces

• 1、 Gürdere, Meliha Burcu,Eme?, Ali Cemal,Aslan, Osman Nuri,Budak, Yakup,Ceylan, Mustafa. "Triethylamin-mediated addition of 2-aminoethanethiol hydrochloride to chalcones: Synthesis of 3-(2-aminoethylthio)-1-(aryl)-3-(thiophen-2-yl) propan-1-ones and 5,7-diaryl-2,3,6, 7-tetrahydro-1,4-thiazepines". . p. 536 - 545. Retrieved 2016/05/02.
• 2、 Gezegen, Hayreddin,Ceylan, Mustafa,Karaman, Isa,?ahin, Ertan. "Synthesis, characterization, and antibacterial activity of novel pyridones". . p. 1084 - 1093. Retrieved 2014/04/03.