Isoquinoline, 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimeth oxy-2-methyl-

Base Information

• Chemical Name: Isoquinoline, 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimeth oxy-2-methyl-
• CAS No.: 54712-52-6
• Molecular Formula: C21H26BrNO4
• Molecular Weight: 436.33900
• Mol file: 54712-52-6.mol

Synonyms:(+/-)2-Bromlaudanosin;(+/-)-1-(2-Brom-4,5-dimethoxy-benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isochinolin;6'-Bromolaudanosin;DL-6'-BROMOLAUDANOSIN;6'-Chlorlaudanosin;dl-6'-Bromlaudanosin;

Chemical Property of Isoquinoline, 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimeth oxy-2-methyl-

Chemical Property:

• PSA: 40.16000
• LogP: 4.19310

Purity/Quality:

DL-6'-BROMOLAUDANOSIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoquinoline, 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimeth oxy-2-methyl-

There total 3 articles about Isoquinoline, 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimeth oxy-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene (53207-00-4) + 2-methyl-6,7-dimethoxy-3,4-dihydroisoquinolinium iodide (30045-07-9) → 6'-bromolaudanosine (54712-52-6,53392-66-8)

Guidance literature:

electroreduction;

DOI:10.1016/S0040-4039(01)82914-2

Reference yield:

4,5,3',4'-tetramethoxy-2-vinyl-stilbene (94757-36-5) → 6'-bromolaudanosine (54712-52-6,53392-66-8)

Guidance literature:

With bromine; acetic acid;

Reference yield:

→ 6'-bromolaudanosine (54712-52-6,53392-66-8)

Guidance literature:

Papaverinhydrochlorid, 1. Brom/W., -Bromierung, 2. Methyljodid, 3. NaBH4, -Red.;

DOI:10.1016/S0040-4020(01)97477-0

upstream raw materials:

4,5,3',4'-tetramethoxy-2-vinyl-stilbene

1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene

2-methyl-6,7-dimethoxy-3,4-dihydroisoquinolinium iodide

Refernces

• 1、 Shono, Tatsuya,Miyamoto, Tetsuya,Mizukami, Masamichi,Hamaguchi, Hiroshi. "ELECTROREDUCTIVE SYNTHESIS OF 1-(BROMOBENZYL)-ISOQUINOLINE DERIVATIVES AND ITS APPLICATION TO CULARINE SYNTHESIS". . p. 2385 - 2388. Retrieved 2007/10/02.