4-Pyridyldiphenylphosphine

Base Information

• Chemical Name: 4-Pyridyldiphenylphosphine
• CAS No.: 54750-98-0
• Molecular Formula: C17H14NP
• Molecular Weight: 263.279
• DSSTox Substance ID: DTXSID50498751
• Nikkaji Number: J1.627.546H
• Wikidata: Q82349004
• Mol file: 54750-98-0.mol

Synonyms:54750-98-0;4-pyridyldiphenylphosphine;SCHEMBL617504;4-(Diphenylphosphanyl)pyridine;4-(Diphenylphosphaneyl)pyridine;DTXSID50498751

Chemical Property of 4-Pyridyldiphenylphosphine

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 263.086386449
• Heavy Atom Count: 19
• Complexity: 232

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=NC=C3

Technology Process of 4-Pyridyldiphenylphosphine

There total 8 articles about 4-Pyridyldiphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-phenoxypyridine (4783-86-2) + diphenylphosphane (829-85-6) → 4-(diphenylphosphino)pyridine (54750-98-0)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 80 ℃; for 15h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03227

Reference yield: 76.0%

4-iodopyridine (15854-87-2) + (diphenylphosphino)(p-tolyl)methanone (40841-62-1) → 4-(diphenylphosphino)pyridine (54750-98-0)

Guidance literature:

With palladium diacetate; caesium carbonate; In toluene; at 80 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.06.088

Reference yield: 73.0%

(diphenylphosphino)(p-tolyl)methanone (40841-62-1) + 4-bromopyridine hydrochloride (19524-06-2) → 4-(diphenylphosphino)pyridine (54750-98-0)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; In toluene; at 100 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.1c00937

upstream raw materials:

4-Chloropyridine

sodium diphenylphosphide

4-bromopyridin

chloro-diphenylphosphine

Downstream raw materials:

[W(CO)4(4-pyridyldiphenylphosphane)]2

[PdCl₂(Zn(OC₆H₂(C(CH₃)3)2CHN)2)2C₆H₂(NC₅H₄P(C₆H₅)2)2]

[PtCl₂(Zn(OC₆H₂(C(CH₃)3)2CHN)2)2C₆H₂(NC₅H₄P(C₆H₅)2)2]

[PtCl₂(Zn(OC₆H₂(C(CH₃)3)2CHN)2)2C₆H₂(NC₅H₄P(C₆H₅)2)2]

Refernces

• 1、 Chen, Xingyu,Wu, Hongyu,Yu, Rongrong,Zhu, Hong,Wang, Zhiqian. "Palladium-Catalyzed C-P(III) Bond Formation by Coupling ArBr/ArOTf with Acylphosphines". . p. 8987 - 8996. Retrieved 2021/06/30.
• 2、 -. "Fluorescent quenching agent based on cobalt metal complex, preparation method and application thereof". Paragraph 0056; 0058-0059. . Retrieved 2020/04/17.