4-(Acetyloxy)benzenepropanoic acid methyl ester

Base Information

• Chemical Name: 4-(Acetyloxy)benzenepropanoic acid methyl ester
• CAS No.: 54965-55-8
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Hs Code.: 2918990090
• Mol file: 54965-55-8.mol

Synonyms:Methyl 3-[4-(acetyloxy)phenyl]propanoate;methyl 3-(4-acetoxyphenyl)propanoate;3-(4-acetoxy-phenyl)-propionic acid methyl ester;3-(4-Acetoxy-phenyl)-propionsaeure-methylester;methyl 3-(4-acetylyphenyl)propanoate;Benzenepropanoic acid,4-(acetyloxy)-,methyl ester;O-Acetyl-dihydro-p-cumarsaeure-methylester;

Chemical Property of 4-(Acetyloxy)benzenepropanoic acid methyl ester

Chemical Property:

• PSA: 52.60000
• LogP: 1.71750

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Acetyloxy)benzenepropanoic acid methyl ester

There total 12 articles about 4-(Acetyloxy)benzenepropanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(4-acetoxyphenyl)-propionic acid (7249-16-3) + methyl iodide (74-88-4) → methyl 3-(4-acetyloxyphenyl)propanoate (54965-55-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 23h;

DOI:10.1021/ja047027t

Reference yield: 69.0%

→ methyl 3-(4-acetyloxyphenyl)propanoate (54965-55-8)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; potassium carbonate; In acetonitrile; at 20 ℃; Irradiation;

Reference yield: 46.0%

4-acetoxyiodobenzene (33527-94-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-(4-acetyloxyphenyl)propanoate (54965-55-8)

Guidance literature:

With bis(cyclopentadienyl)titanium dichloride; manganese; chloro-trimethyl-silane; triphenylphosphine; nickel dichloride; In tetrahydrofuran; at 50 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jo402626u

upstream raw materials:

methyl (2E)-3-[4-(acetyloxy)phenyl]-2-propenoate

3-(4-acetoxyphenyl)-propionic acid

methyl iodide

3-(4-hydroxyphenyl)propionic acid methyl ester

Downstream raw materials:

3-(4-hydroxyphenyl)propan-1-ol

Refernces

• 1、 Gehrtz,Hirschbeck,Fleischer. "A recyclable CO surrogate in regioselective alkoxycarbonylation of alkenes: Indirect use of carbon dioxide". supporting information. p. 12574 - 12577. Retrieved 2015/08/06.
• 2、 Gonzalez-Sebastian, Lucero,Flores-Alamo, Marcos,Garcia, Juventino J.. "Nickel-catalyzed reductive hydroesterification of styrenes using CO 2 and MeOH". . p. 8200 - 8207. Retrieved 2013/02/22.