Benzeneacetic acid, a-oxo-, butyl ester

Base Information

• Chemical Name: Benzeneacetic acid, a-oxo-, butyl ester
• CAS No.: 5524-55-0
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Mol file: 5524-55-0.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-oxo-, butyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a-oxo-, butyl ester

There total 27 articles about Benzeneacetic acid, a-oxo-, butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Benzoylformic acid (611-73-4) + butan-1-ol (71-36-3) → n-butyl 2-oxo-2-phenylacetate (5524-55-0)

Guidance literature:

With graphene oxide; In 1,2-dichloro-ethane; at 100 ℃; for 24h;

DOI:10.1055/s-0036-1588399

Reference yield: 95.0%

phenylglyoxal hydrate (1074-12-0) + butan-1-ol (71-36-3) → n-butyl 2-oxo-2-phenylacetate (5524-55-0)

Guidance literature:

With pyridine; oxygen; copper(I) triflate; trifluoroacetic acid; In toluene; at 130 ℃; for 24h;

DOI:10.1021/ol503472x

Reference yield: 95.0%

1-phenyl-2-hydroxyethanone (582-24-1) + butan-1-ol (71-36-3) → n-butyl 2-oxo-2-phenylacetate (5524-55-0)

Guidance literature:

With oxygen; at 70 ℃; for 12h; Schlenk technique; Sealed tube;

DOI:10.1021/acs.oprd.8b00265

upstream raw materials:

di-n-butyl oxalate

phenylglyoxylyl chloride

butan-1-ol

iodobenzene

Downstream raw materials:

(R)-mandelic acid n-butyl ester

benzoic acid, butyl ester

benzaldehyde

butyraldehyde

Refernces

• 1、 Luo, Xianglin,He, Runfa,Liu, Qiang,Gao, Yanping,Li, Jingqing,Chen, Xiuwen,Zhu, Zhongzhi,Huang, Yubing,Li, Yibiao. "Metal-Free Oxidative Esterification of Ketones and Potassium Xanthates: Selective Synthesis of α-Ketoesters and Esters". . p. 5220 - 5230. Retrieved 2020/05/18.
• 2、 Yu, Qing,Zhang, Yating,Wan, Jie-Ping. "Ambient and aerobic carbon-carbon bond cleavage toward α-ketoester synthesis by transition-metal-free photocatalysis". supporting information. p. 3436 - 3441. Retrieved 2019/06/24.