Trazodone N-Oxide

Base Information

• Chemical Name: Trazodone N-Oxide
• CAS No.: 55290-68-1
• Molecular Formula: C19H22ClN5O2
• Molecular Weight: 387.86300
• Mol file: 55290-68-1.mol

Synonyms:2-[3-[4-(3-chlorophenyl)-1-oxidopiperazin-1-ium-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one;

Chemical Property of Trazodone N-Oxide

Chemical Property:

• Melting Point: 119 - 122°C
• PSA: 71.97000
• LogP: 2.39810
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Trazodone N-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Trazodone N-Oxide is a metabolite of Trazodone-HCl (T718500). Trazodone impurity A. A metabolite of Trazodone-HCl [25332-39-2] Trazodone N-Oxide

Technology Process of Trazodone N-Oxide

There total 2 articles about Trazodone N-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trazodone hydrochloride (25332-39-2,19666-36-5) → 1-(3-chlorophenyl)-4-(3-(3-oxo-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl)piperazine 1,4-dioxide + 1-(3-chlorophenyl)-4-(3-(3-oxo-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl)piperazine 1-oxide + 4‐(3‐chlorophenyl)‐1‐(3‐(3‐oxo‐[1,2,4]triazolo[4,3‐a]pyridin‐2(3H)‐yl)propyl)piperazine 1‐oxide (55290-68-1)

Guidance literature:

With dihydrogen peroxide; In water; at 20 ℃; for 24h;

DOI:10.1039/c8nj03545h

Reference yield:

→ 4‐(3‐chlorophenyl)‐1‐(3‐(3‐oxo‐[1,2,4]triazolo[4,3‐a]pyridin‐2(3H)‐yl)propyl)piperazine 1‐oxide (55290-68-1)

Guidance literature:

Trazodon, Perbenzoesaeure;

upstream raw materials:

trazodone hydrochloride

Refernces