2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE

Base Information

• Chemical Name: 2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE
• CAS No.: 55317-02-7
• Molecular Formula: C9H10O5
• Molecular Weight: 198.175
• Mol file: 55317-02-7.mol

Synonyms:2',4',6'-trihydroxy-2-methoxyacetophenone;2-methoxy-1-(2,4,6-trihydroxyphenyl)ethan-1-one;2-Methoxy-1-(2,4,6-trihydroxy-phenyl)-aethanon;2-methoxy-1-(2,4,6-trihydroxyphenyl) ethanone;ethanone,2-methoxy-1-(2,4,6-trihydroxyphenyl);2',4',6'-trihydroxy-1-methoxyacetophenone;

Chemical Property of 2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE

Chemical Property:

• Melting Point: 195–196°C
• PSA: 86.99000
• LogP: 0.63250

Purity/Quality:

97% ^*data from raw suppliers

2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE

There total 7 articles about 2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,5-dihydroxyphenol (108-73-6) + 2-methoxyacetonitrile (1738-36-9) → 2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone (55317-02-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 7h;

Reference yield: 87.0%

2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanimine hydrochloride → 2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone (55317-02-7)

Guidance literature:

With water; at 0 - 90 ℃; for 6h; Large scale;

Reference yield: 51.0%

3,5-dihydroxyphenol (108-73-6) + Methoxyacetyl chloride (38870-89-2) → 2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone (55317-02-7)

Guidance literature:

With aluminum (III) chloride; In ethyl acetate; at 20 - 30 ℃; for 24h; Inert atmosphere; Large scale;

upstream raw materials:

3,5-dihydroxyphenol

2-methoxyacetonitrile

Methoxyacetyl chloride

Downstream raw materials:

4'-(benzyloxy)-5,7-dihydroxy-3-methoxyflavone

3',4'-bis(benzyloxy)-5,7-dihydroxy-3-methoxyflavone

5,7-dihydroxy-3-methoxy-2-(3-methoxy-phenyl)-chromen-4-one

5,7-dihydroxy-3-methoxy-2-(2,4,5-trimethoxy-phenyl)-chromen-4-one

Refernces

• 1、 -. "Preparation method of flavone compound intermediate". Paragraph 0073; 0077; 0079. . Retrieved 2019/10/01.
• 2、 -. "SYNTHESIS OF POLYHYDROXY CHROMENONE COMPOUNDS AND THEIR ANTI-TUMOR EFFECTS". Paragraph 0081. . Retrieved 2015/02/18.