1-Hydroxy-8-methoxyanthraquinone

Base Information

• Chemical Name: 1-Hydroxy-8-methoxyanthraquinone
• CAS No.: 5539-66-2
• Molecular Formula: C15H10O4
• Molecular Weight: 254.242
• Hs Code.: 2914690090
• Mol file: 5539-66-2.mol

Synonyms:Danthron methyl derivative;1-hydroxy-8-methoxy-9,10-anthracenedione;8-hydroxy-1-methoxy-9,10-anthraquinone;1-Hydroxy-8-methoxy-9,10-anthrachinon;8-hydroxy-1-methoxy-9,10-anthracenedione;1-hidroxi-8-methoxi-9,10-antraquinona;1-Hydroxy-8-methoxyanthraquinone;1-hydroxy-8-methoxy-9,10-anthraquinone;9,10-Anthracenedione,1-hydroxy-8-methoxy;1-Hydroxy-8-methoxyanthra-9,10-quinone;

Chemical Property of 1-Hydroxy-8-methoxyanthraquinone

Chemical Property:

• Melting Point: 196.8-198 °C
• Boiling Point: 480.5±45.0 °C(Predicted)
• PKA: 6.75±0.20(Predicted)
• PSA: 63.60000
• Density: 1.400±0.06 g/cm3(Predicted)
• LogP: 2.17620
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

1-HYDROXY-8-METHOXY-ANTHRAQUINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Hydroxy-8-methoxyanthraquinone

There total 22 articles about 1-Hydroxy-8-methoxyanthraquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,8-dimethoxy-9,10-anthracenedione (6407-55-2) → 1-hydroxy-8-methoxyanthraquinone (5539-66-2)

Guidance literature:

With hydrogen bromide; In acetic acid; for 16h; Ambient temperature;

DOI:10.1021/jm00087a014

Reference yield: 100.0%

8-Hydroxy-1,1,4-trimethoxy-1,4,4a,9a-tetrahydro-anthraquinone (84399-87-1) → 1-hydroxy-8-methoxyanthraquinone (5539-66-2)

Guidance literature:

at 130 ℃; sublimation in vac.;

DOI:10.1016/S0040-4039(01)92528-6

Reference yield: 97.0%

1-Acetoxy-8-methoxy-9,10-anthrachinon (75312-39-9) → 1-hydroxy-8-methoxyanthraquinone (5539-66-2)

Guidance literature:

With sodium hydroxide; In ethanol; for 5h;

DOI:10.1002/jlac.198419840213

upstream raw materials:

4-hydroxy-5-methoxy-anthrone

1,4-dihydroxy-9,10-anthracenedione

dimethyl sulfate

N,N’-diisopropyl-O-methylisourea

Downstream raw materials:

2-(1-Hydroxy-8-methoxy-9,10-dioxo-9,10-dihydro-anthracen-2-ylmethyl)-benzoic acid

4-[(9,10-dihydro-9,10-dioxo-1-hydroxy-8-methoxy-2-anthracenyl)hydroxymethyl]benzonitrile

1,8-dimethoxy-9,10-anthracenedione

1,8-diacetoxy-9,10-anthraquinone

Refernces

• 1、 Li, Yang,Cao, Rui,Lippard, Stephen J.. "Design and synthesis of a novel triptycene-based ligand for modeling carboxylate-bridged diiron enzyme active sites". . p. 5052 - 5055. Retrieved 2011.
• 2、 Gao, Liming,Guan, Jing,Lyu, Lili,Ma, Mingliang,Shan, Bin,Tan, Weiqiang,Xia, Yan,Yang, Qipeng,Zhan, Xiuzhi,Zheng, Jifang. "An efficient synthesis of 9-anthrone lactone derivatives via the Knoevenagel condensation and intramolecular cyclization". supporting information. . Retrieved 2020/02/15.
• 3、 Xiang, Haoyue,Yang, Chunhao. "A facile and general approach to 3-((trifluoromethyl)thio)-4 H -chromen-4-one". supporting information. p. 5686 - 5689. Retrieved 2015/02/19.