1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE

Base Information

• Chemical Name: 1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE
• CAS No.: 55400-73-2
• Molecular Formula: C10H22O9S2
• Molecular Weight: 350.411
• Mol file: 55400-73-2.mol

Synonyms:LogP

Chemical Property of 1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE

Chemical Property:

• Vapor Pressure: 6.3E-11mmHg at 25°C
• Refractive Index: 1.47
• Boiling Point: 533.6°C at 760 mmHg
• Flash Point: 276.5°C
• PSA: 131.19000
• Density: 1.31g/cm³
• LogP: 1.15020
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility.: Dichloromethane

Purity/Quality:

99.3% ^*data from raw suppliers

1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Ms-PEG5-Ms are PEG linkers containing two mesyl moieties. The mesyl groups are good leaving groups and can also be used as protecting groups for primary alcohols. They can be deprotected in the presence of sodium amalgam. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Technology Process of 1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE

There total 2 articles about 1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Tetraethylene glycol (112-60-7) + methanesulfonyl chloride (124-63-0) → ((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate (55400-73-2) + 2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl methanesulfonate (65883-12-7)

Guidance literature:

With silver(l) oxide; In dichloromethane; for 48h;

DOI:10.1021/jo0012290

Reference yield:

N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)-5-(dimethylamino)naphthalene-1-sulfonamide (914311-67-4) + methanesulfonyl chloride (124-63-0) → ((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate (55400-73-2) + 2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl methanesulfonate (65883-12-7)

Guidance literature:

With silver(l) oxide; In dichloromethane; Inert atmosphere;

DOI:10.1021/ja204488p

Reference yield: 58.0%

5-(benzyloxy)-2-(4-hydroxyphenyl)-7-(methoxymethoxy)-4H-chromen-4-one (916330-61-5) + ((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate (55400-73-2) → 12-[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-3,6,9,12-tetraoxadodecan-1-ol (916330-95-5) + 1,13-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane (916330-72-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Heating;

DOI:10.1021/jm060593+

upstream raw materials:

Tetraethylene glycol

methanesulfonyl chloride

N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)-5-(dimethylamino)naphthalene-1-sulfonamide

Downstream raw materials:

6,9,12,15,18-Pentaoxa-1,23-tricosandiol

octaethylene glycol dimethyl ether

N-(2-methoxyphenyl)monoaza-18-crown-6

phenylphosphadibenzo-18-crown-6

Refernces

• 1、 Svedhem,Hollander,Shi,Konradsson,Liedberg,Svensson. "Synthesis of a series of oligo(ethylene glycol)-terminated alkanethiol amides designed to address structure and stability of biosensing interfaces". . p. 4494 - 4503. Retrieved 2007/10/03.