N,2-dimethyl-N-phenylpropanamide

Base Information

• Chemical Name: N,2-dimethyl-N-phenylpropanamide
• CAS No.: 55577-65-6
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Mol file: 55577-65-6.mol

Synonyms:

Chemical Property of N,2-dimethyl-N-phenylpropanamide

Chemical Property:

• PSA: 20.31000
• LogP: 2.30540

Purity/Quality:

N,2-DIMETHYL-N-PHENYLPROPANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,2-dimethyl-N-phenylpropanamide

There total 13 articles about N,2-dimethyl-N-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

isobutyric Acid (79-31-2) + N-methylaniline (100-61-8) → 2,N-dimethyl-N-phenylpropanamide (55577-65-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.01.024

Reference yield: 88.0%

isobutyryl chloride (79-30-1) + N-methylaniline (100-61-8) → 2,N-dimethyl-N-phenylpropanamide (55577-65-6)

Guidance literature:

With triethylamine; In diethyl ether; for 5h; Ambient temperature;

DOI:10.1002/hlca.19830660126

Reference yield: 78.0%

isobutyraldehyde (78-84-2) + N-methylaniline (100-61-8) → 2,N-dimethyl-N-phenylpropanamide (55577-65-6)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 2,2,2-Trifluoroacetophenone; 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene; In 1,4-dioxane; at 30 ℃; for 8h; Inert atmosphere; Glovebox;

DOI:10.1002/anie.201410322

upstream raw materials:

N-methylaniline

2-isopropylidene-5,5-dimethyl-[1,3]dioxane-4,6-dione

2-bromo-2,N-dimethyl-N-phenylpropanamide

isobutyryl chloride

Downstream raw materials:

2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine

N,2-dimethyl-N-phenylpropanethioamide

2-bromo-2,N-dimethyl-N-phenylpropanamide

1-(1-chloro-2-methylprop-1-enyl)-N-methyl-N-phenylamine

Refernces

• 1、 Chen, Jian-Qiang,Wei, Yun-Long,Xu, Guo-Qiang,Liang, Yong-Min,Xu, Peng-Fei. "Intramolecular 1,5-H transfer reaction of aryl iodides through visible-light photoredox catalysis: A concise method for the synthesis of natural product scaffolds". supporting information. p. 6455 - 6458. Retrieved 2016/05/24.
• 2、 Ojha, Devi Prasan,Gadde, Karthik,Prabhu, Kandikere Ramaiah. "Generation of Hydrogen from Water: A Pd-Catalyzed Reduction of Water Using Diboron Reagent at Ambient Conditions". supporting information. p. 5062 - 5065. Retrieved 2016/10/14.