1,4-Dioxan-2-ol, benzoate

Base Information

• Chemical Name: 1,4-Dioxan-2-ol, benzoate
• CAS No.: 55644-06-9
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Mol file: 55644-06-9.mol

Synonyms:1,4-Dioxan-2-ol,benzoate;2-Benzyloxy-1,4-dioxan;1,4-dioxan-2-ylbenzoate;

Chemical Property of 1,4-Dioxan-2-ol, benzoate

Chemical Property:

• PSA: 75.99000
• LogP: 0.73640

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Dioxan-2-ol, benzoate

There total 18 articles about 1,4-Dioxan-2-ol, benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + benzoic acid (65-85-0,8013-63-6) → benzoic acid [1,4]dioxan-2-yl ester (55644-06-9)

Guidance literature:

With di-tert-butyl peroxide; copper 5,10,15-tris(pentafluorophenyl)corrole; at 120 ℃; for 12h; Reagent/catalyst; Catalytic behavior; Mechanism; Schlenk technique;

DOI:10.3987/COM-21-14408

Reference yield: 96.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + Benzoylformic acid (611-73-4) → benzoic acid [1,4]dioxan-2-yl ester (55644-06-9)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; at 80 ℃; for 4h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c3ob40748a

Reference yield: 83.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + toluene (108-88-3,15644-74-3,16713-13-6) → benzoic acid [1,4]dioxan-2-yl ester (55644-06-9)

Guidance literature:

With tert.-butylhydroperoxide; at 80 ℃; for 10h; Green chemistry;

DOI:10.1055/s-0035-1560067

upstream raw materials:

1,4-dioxane

dibenzoyl peroxide

1,4-dioxane-d8

benzoic acid

Downstream raw materials:

glyoxal bis-(2,4-dinitrophenylhydrazone)

Refernces

• 1、 Liu, Zhao-Yang,Peng, Wei-Yu,Akram, Waseem,Lai, Jia-Wei,Zhang, Hao,Liu, Hai-Yang. "Copper corrole catalyzed esterification of C(sp3)-H with carboxylic acids via cross-dehydrogenative coupling reaction". . p. 860 - 870. Retrieved 2021/05/19.
• 2、 Wang, Hua-Hua,Wen, Wei-Hong,Zou, Huai-Bo,Cheng, Fan,Ali, Atif,Shi, Lei,Liu, Hai-Yang,Chang, Chi-Kwong. "Copper porphyrin catalyzed esterification of C(sp3)-H via a cross-dehydrogenative coupling reaction". . p. 3508 - 3514. Retrieved 2017/07/12.