6-CHLORO-3-FORMYLCHROMONE

Base Information

• Chemical Name: 6-CHLORO-3-FORMYLCHROMONE
• CAS No.: 42248-31-7
• Molecular Formula: C10H5ClO3
• Molecular Weight: 208.601
• Hs Code.: 29329900
• Mol file: 42248-31-7.mol

Synonyms:6-Chloro-3-formylchromone;6-Chlorochromone-3-carboxaldehyde;

Chemical Property of 6-CHLORO-3-FORMYLCHROMONE

Chemical Property:

• Appearance/Colour: yellow crystalline powder
• Vapor Pressure: 3.98E-05mmHg at 25°C
• Melting Point: 166-168 °C(lit.)
• Refractive Index: 1.693
• Boiling Point: 351.896 °C at 760 mmHg
• Flash Point: 161.508 °C
• PSA: 47.28000
• Density: 1.561 g/cm³
• LogP: 2.25890

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloro-4-oxo-4H-chromene-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-3-FORMYLCHROMONE

There total 10 articles about 6-CHLORO-3-FORMYLCHROMONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

5-chloro-2-hydroxyacetophenone (1450-74-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-Chloro-4-oxo-4H-chromene-3-carbaldehyde (42248-31-7)

Guidance literature:

With trichlorophosphate; In water; at 0 - 25 ℃; for 12h;

DOI:10.24820/ARK.5550190.P011.356

Reference yield: 91.0%

acetoxy(6-chloro-4-oxo-4H-chromen-3-yl)methyl acetate → 6-Chloro-4-oxo-4H-chromene-3-carbaldehyde (42248-31-7)

Guidance literature:

With ammonium cerium(IV) nitrate; In water; acetonitrile; at 70 ℃; for 2h;

Reference yield: 89.0%

1-(2-chlorophenyl)-2-hydroxyethanone (133662-20-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-Chloro-4-oxo-4H-chromene-3-carbaldehyde (42248-31-7)

Guidance literature:

With trichlorophosphate; at 20 ℃; Cooling with ice;

DOI:10.1039/c2ob25889g

upstream raw materials:

3-(5-chloro-2-hydroxy-phenyl)-3-oxo-propionaldehyde

N,N-dimethyl-formamide

5-chloro-2-hydroxyacetophenone

4-chlorophenyl acetate

Downstream raw materials:

6-Chloro-3-[1-(4-chloro-phenylamino)-meth-(E)-ylidene]-2-ethoxy-chroman-4-one

(2-Amino-pyrimidin-5-yl)-(5-chloro-2-hydroxy-phenyl)-methanone

6-Chloro-2-ethoxy-3-[1-phenylamino-meth-(E)-ylidene]-chroman-4-one

3-{[(Z)-2-Amino-phenylimino]-methyl}-6-chloro-chromen-4-one

Refernces

• 1、 -. "Chromone dioxadiazole compound as well as preparation method and application thereof". Paragraph 0021-0023. . Retrieved 2021/10/30.
• 2、 Bhatia, Richa Kaur,Coutinho, Evans C.,Garg, Ruchika,Kancherla, Satyavathi,Kaur, Maninder,Madan, Jitender,Pissurlenkar, Raghuvir R. S.,Singh, Lakhwinder,Yadav, Manmohan. "Novel p-functionalized chromen-4-on-3-yl chalcones bearing astonishing boronic acid moiety as MDM2 inhibitor: Synthesis, cytotoxic evaluation and simulation studies". . p. 212 - 228. Retrieved 2020/03/10.