benzyl (chlorocarbonyl)phenylacetate

Base Information

• Chemical Name: benzyl (chlorocarbonyl)phenylacetate
• CAS No.: 35353-13-0
• Molecular Formula: C16H13 Cl O3
• Molecular Weight: 288.73
• Hs Code.: 2918300090
• Mol file: 35353-13-0.mol

Synonyms:benzyl (chlorocarbonyl)phenylacetate

Chemical Property of benzyl (chlorocarbonyl)phenylacetate

Chemical Property:

• Vapor Pressure: 4.05E-07mmHg at 25°C
• Boiling Point: 415.7°Cat760mmHg
• Flash Point: 163.8°C
• PSA: 43.37000
• Density: 1.258g/cm³
• LogP: 3.27900

Purity/Quality:

99% ^*data from raw suppliers

BENZYL(CHLOROCARBONYL)PHENYLACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl (chlorocarbonyl)phenylacetate

There total 2 articles about benzyl (chlorocarbonyl)phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

monobenzyl phenylmalonate (25774-02-1) → phenyl-2-(benzyloxycarbonyl)acetyl chloride (35353-13-0)

Guidance literature:

With tetramethyl-α-chloroenamine; In tetrahydrofuran; at 0 - 25 ℃; for 3h;

Reference yield:

→ phenyl-2-(benzyloxycarbonyl)acetyl chloride (35353-13-0)

Guidance literature:

Benzylphenylmalonsaeure, Oxalylchlorid;

Reference yield: 53.0%

phenyl-2-(benzyloxycarbonyl)acetyl chloride (35353-13-0) + N-methylhydroxyamine hydrochloride (4229-44-1) → N-hydroxy-N-methyl-2-phenyl-malonamic acid benzyl ester

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; methanol; at 0 ℃;

DOI:10.1016/j.tetlet.2003.08.098

upstream raw materials:

monobenzyl phenylmalonate

Downstream raw materials:

tert-butyl (+/-)-7β-(2-benzyloxycarbonyl-2-phenylacetamido)-3-trifluoromethyl-3-cephem-4-carboxylate

(3S,7aR)-6-(2-Benzyloxycarbonyl-2-phenyl-acetyl)-2,2-dimethyl-5-oxo-hexahydro-imidazo[5,1-b]thiazole-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Refernces

• 1、 -. "6α, β-Substituted penicillin derivatives". . . Retrieved 2008/06/13.