Technology Process of Benzenepropanoyl chloride, a-phenyl-
There total 8 articles about Benzenepropanoyl chloride, a-phenyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 18h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
3.1: thionyl chloride / 2.5 h / 25 - 70 °C / Inert atmosphere
With
thionyl chloride; water; lithium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran;
DOI:10.1016/j.tet.2019.05.065
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 20 - 25 °C / Inert atmosphere
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 - 25 °C
With
n-butyllithium; oxalyl dichloride; diisopropylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/anie.202004354