(2-Chlorophenyl)diphenylmethane

Base Information

• Chemical Name: (2-Chlorophenyl)diphenylmethane
• CAS No.: 56153-60-7
• Molecular Formula: C19H15Cl
• Molecular Weight: 278.781
• European Community (EC) Number: 641-543-9
• UNII: R037PQP71D
• ChEMBL ID: CHEMBL1176
• Metabolomics Workbench ID: 71893
• Nikkaji Number: J1.201.904A
• Wikidata: Q27287586
• Mol file: 56153-60-7.mol

Synonyms:(2-Chlorophenyl)diphenylmethane;56153-60-7;1-Benzhydryl-2-chlorobenzene;1-Chloro-2-(diphenylmethyl)benzene;R037PQP71D;((2-Chlorophenyl)methylene)dibenzene;Benzene, 1-chloro-2-(diphenylmethyl)-;starbld0002966;Chlorodiphenylmethylbenzene;Chloromethanetriyltribenzene;Triphenylmethane, 2-chloro;CHEMBL1176;UNII-R037PQP71D;SCHEMBL41575;2-chloro-phenylbisphenylmethane;AKOS015849925;2-CHLOROPHENYL-BISPHENYLMETHANE(MAJOR);Q27287586

Chemical Property of (2-Chlorophenyl)diphenylmethane

Chemical Property:

• Melting Point: 77 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 376.6±11.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.139±0.06 g/cm3(Predicted)
• LogP: 5.52020
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig
• XLogP3: 5.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 3
• Exact Mass: 278.0862282
• Heavy Atom Count: 20
• Complexity: 258

Purity/Quality:

98% ^*data from raw suppliers

(2-Chlorophenyl)diphenylmethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)C3=CC=CC=C3Cl
• Uses: (2-Chlorophenyl)diphenylmethane is a triarylmethane with antiproliferative activity. (2-Chlorophenyl)diphenylmethane is an impurity of the antifungal agent Clotrimazole (C587400).

Technology Process of (2-Chlorophenyl)diphenylmethane

There total 9 articles about (2-Chlorophenyl)diphenylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-bis-(2-chloro-phenyl)-2,2-diphenyl-ethanone (43014-48-8) → 1-(2-chlorophenyl)-1,1-diphenyl methane (56153-60-7) + ortho-chlorobenzoic acid (118-91-2)

Guidance literature:

at 100 ℃; im Rohr;

Reference yield:

dimethylsulfoxide-d6 (2206-27-1) + o-chlorotriphenylmethanol (66774-02-5) → 1-(2-chlorophenyl)-1,1-diphenyl methane (56153-60-7)

Guidance literature:

With chloro-trimethyl-silane; sodium iodide; In hexane; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

o-chlorotriphenylmethanol (66774-02-5) → 1-(2-chlorophenyl)-1,1-diphenyl methane (56153-60-7)

Guidance literature:

With hydrogen iodide; acetic acid;

upstream raw materials:

formaldehyd

o-chlorotriphenylmethanol

1,2-bis-(2-chloro-phenyl)-2,2-diphenyl-ethanone

clotrimazole

Downstream raw materials:

2-(diphenylmethyl)benzophenone

9-ethyl-10-phenyl-anthracene

9-methyl-10-phenylanthracene

9,10-diphenylanthracene

Refernces

• 1、 -. "Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction". . . Retrieved 2008/06/13.
• 2、 -. "Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation.". . . Retrieved 2008/06/13.