DSIP

Base Information

• Chemical Name: DSIP
• CAS No.: 62568-57-4
• Molecular Formula: C35H48N10O15
• Molecular Weight: 848.824
• Mol file: 62568-57-4.mol

Synonyms:11:PN: US20070269902 SEQID: 11 unclaimed sequence;1261: PN: US20090175821 SEQID:1547 claimed protein;1: PN: US20090142851 SEQID: 1 claimed protein;1: PN:WO0045832 PAGE: 16 claimed protein;1: PN: WO2008015768 SEQID: 1 unclaimedsequence;243: PN: WO0069900 SEQID: 1547 unclaimed sequence;2: PN: WO0045832PAGE: 16 claimed protein;2: PN: WO2004072106 SEQID: 2 claimed protein;694:PN: WO2004005342 PAGE: 46 claimed protein;DSIP nonapeptide;Emideltide;L-Glutamicacid, L-tryptophyl-L-alanylglycylglycyl-L-a-aspartyl-L-alanyl-L-serylglycyl-;L-Glutamicacid, N-[N-[N-[N-[N-[N-[N-(N-L-tryptophyl-L-alanyl)glycyl]glycyl]-L-a-aspartyl]-L-alanyl]-L-seryl]glycyl]-;L-Tryptophyl-L-alanylglycylglycyl-L-a-aspartyl-L-alanyl-L-serylglycyl-L-glutamic acid;Delta Sleep Inducing Peptide;

Chemical Property of DSIP

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.612
• Boiling Point: 1522.7 °C at 760 mmHg
• PKA: 3.18±0.10(Predicted)
• Flash Point: 874.7 °C
• PSA: 406.74000
• Density: 1.458 g/cm³
• LogP: -1.90600
• Storage Temp.: −20°C
• Water Solubility.: Soluble in water at 0.5mg/ml

Purity/Quality:

99.89% ^*data from raw suppliers

Delta Sleep Inducing Peptide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Delta-sleep-inducing peptide (DSIP) is a neuropeptide with amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and molecular mass 848.81 g/mol. DSIP occurs in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). Delta-sleep-inducing peptide is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.
• Uses: Delta-sleep-inducing peptide (DSIP) was isolated, characterized, and synthesized more than 6 years ago. It can help relieve stress and aches that keep you from restful sleep. It was first proposed as a sleep-peptide and this remains the prevalent impression of its function. DSIP is a natural sleep-promoting nonapeptide with a few beneficial functions. The peptide has been used to treat poor sleep, pain conditions, stress-related symptoms, and more. Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt is a useful research chemical compound.

Technology Process of DSIP

There total 4 articles about DSIP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Nα-Z-L-tryptophyl-L-alanyl-glycyl-glycyl-β-benzyl-L-aspartyl-L-alanyl-O-benzyl-L-seryl-glycyl-L-glutamic acid dibenzyl ester → Delta sleep-inducing peptide (rabbit) (62568-57-4)

Guidance literature:

With hydrogen; palladium; In acetic acid; N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

Fmoc-Trp-Ala-Gly-Gly-Asp(OBzl)-Ala-Ser(OBzl)-Gly-Glu(OBzl)-OBzl (130738-28-2) → Delta sleep-inducing peptide (rabbit) (62568-57-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; Yield given; 2-4 h;

DOI:10.1055/s-1990-27032

Reference yield:

benzyloxycarbonyltryptophanyl-alanyl-glycyl-glycyl-aspartyl-alanyl-seryl-glycyl-glutamic acid → Delta sleep-inducing peptide (rabbit) (62568-57-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Yield given;

upstream raw materials:

Fmoc-Trp-Ala-Gly-Gly-Asp(OBzl)-Ala-Ser(OBzl)-Gly-Glu(OBzl)-OBzl

BOC-glycine

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Fmoc-Ser(tBu)-OH

Downstream raw materials:

L-alanin

L-serin

L-glutamic acid

glycine

Refernces

• 1、 Wang,Xu. "One-pot liquid-phase synthesis of DSIP and 5-phe-DSIP using fluoren-9-yl-methoxycarbonyl-protected amino acid pentafluorophenyl esters". . p. 845 - 846. Retrieved 2007/10/02.
• 2、 Nozaki,Muramatsu. "Rapid peptide synthesis in liquid phase. Preparation of angiotensin II and delta-sleep-inducing peptide by the 'hold-in' solution method". . p. 2165 - 2168. Retrieved 2007/10/02.