isopropyl 3-broMo-2-oxopropanoate

Base Information

• Chemical Name: isopropyl 3-broMo-2-oxopropanoate
• CAS No.: 56417-63-1
• Molecular Formula: C6H9BrO3
• Molecular Weight: 209.04
• Mol file: 56417-63-1.mol

Synonyms:

Chemical Property of isopropyl 3-broMo-2-oxopropanoate

Chemical Property:

• Boiling Point: 213.0±23.0 °C(Predicted)
• Density: 1.474±0.06 g/cm3(Predicted)

Purity/Quality:

≥95% ^*data from raw suppliers

Isopropyl3-Bromo-2-oxopropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of isopropyl 3-broMo-2-oxopropanoate

There total 1 articles about isopropyl 3-broMo-2-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromopyruvic acid (1113-59-3) + isopropyl alcohol (67-63-0,8013-70-5) → iso-propyl 3-bromo-2-oxopropanoate (56417-63-1) + isopropyl 3-chloro-2-oxopropionate (942148-14-3)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 3.5h;

Reference yield: 78.0%

iso-propyl 3-bromo-2-oxopropanoate (56417-63-1) + triphenylphosphine (603-35-0) → iso-propyl 2-oxo-3-(triphenyl-λ5-phosphaneylidene)propanoate

Guidance literature:

iso-propyl 3-bromo-2-oxopropanoate; triphenylphosphine; In tetrahydrofuran; at 60 ℃; for 2h; Inert atmosphere;

With potassium hydroxide; In dichloromethane; water; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/adsc.202100785

Reference yield: 61.2%

iso-propyl 3-bromo-2-oxopropanoate (56417-63-1) + 2-(5-benzyl-5,7a-dihydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-2-methylpropan-1-amine → isopropyl 2-benzyl-10,10-dimethyl-2,8,9,10-tetrahydropyrido[3',4':4,5]pyrrolo[2,3-d]azepine-6-carboxylate

Guidance literature:

2-(5-benzyl-5,7a-dihydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-2-methylpropan-1-amine; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h; Inert atmosphere;

iso-propyl 3-bromo-2-oxopropanoate; In isopropyl alcohol; at 80 ℃; for 5h;

With pyridine; at 100 ℃; for 3h;

upstream raw materials:

bromopyruvic acid

isopropyl alcohol

Downstream raw materials:

isopropyl 1,1-dimethyl-1,2,3,6-tetrahydro-azepino[4,5-b]indole-5-carboxylate

isopropyl 8-fluoro-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate

Refernces