1,4-Bis(chloromethyl)-2,5-dimethoxybenzene

Base Information

• Chemical Name: 1,4-Bis(chloromethyl)-2,5-dimethoxybenzene
• CAS No.: 3752-97-4
• Molecular Formula: C10H12Cl2O2
• Molecular Weight: 235.11
• Hs Code.: 2909309090
• European Community (EC) Number: 622-776-5
• DSSTox Substance ID: DTXSID9063166
• Nikkaji Number: J421.696B
• Wikidata: Q81990528
• Mol file: 3752-97-4.mol

Synonyms:1,4-bis(chloromethyl)-2,5-dimethoxybenzene;3752-97-4;2,5-Bis(chloromethyl)-1,4-dimethoxybenzene;Benzene, 1,4-bis(chloromethyl)-2,5-dimethoxy-;YSZC374;SCHEMBL3372657;DTXSID9063166;2,5-Dimethoxy-p-xylylene dichloride;BBL036230;STL445244;AKOS003348564;VS-13372;1,4-bis-(Chlormethyl)-2,5-dimethoxybenzene;FT-0606794;Benzene,1,4-bis(chloromethyl)-2,5-dimethoxy-;2,5-Bis(chloromethyl)-1,4-dimethoxybenzene, tech

Chemical Property of 1,4-Bis(chloromethyl)-2,5-dimethoxybenzene

Chemical Property:

• Vapor Pressure: 0.000346mmHg at 25°C
• Melting Point: 164 °C
• Refractive Index: 1.525
• Boiling Point: 329.2 °C at 760 mmHg
• Flash Point: 126.2 °C
• PSA: 18.46000
• Density: 1.219 g/cm³
• LogP: 3.18140
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 234.0214350
• Heavy Atom Count: 14
• Complexity: 148

Purity/Quality:

98%Min ^*data from raw suppliers

2,5-Bis(chloromethyl)-1,4-dimethoxybenzene, tech ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1CCl)OC)CCl

Technology Process of 1,4-Bis(chloromethyl)-2,5-dimethoxybenzene

There total 7 articles about 1,4-Bis(chloromethyl)-2,5-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,4-dimethoxybezene (150-78-7) → 1,4-bis(chloromethyl)-2,5-dimethoxybenzene (3752-97-4)

Guidance literature:

With hydrogenchloride; In water; methyl cyclohexane; at 60 ℃; for 8h;

DOI:10.1007/BF03246210

Reference yield:

1,4-dimethoxybezene (150-78-7) → 1,4-bis(chloromethyl)-2,5-dimethoxybenzene (3752-97-4)

Guidance literature:

With hydrogenchloride; formaldehyd; at 20 ℃;

Reference yield:

1,4-dihydroxymethyl-2,5-dimethoxybenzaldehyde (51829-43-7) → 1,4-bis(chloromethyl)-2,5-dimethoxybenzene (3752-97-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 90 ℃; for 1h;

DOI:10.1021/jacs.0c03691

upstream raw materials:

1,4-dimethoxybezene

formaldehyd

Octanethiol

hydrogenchloride

Downstream raw materials:

1,4-bis(triphenylphosphoniomethyl)-2,5-dimethoxybenzene dichloride

tetraethyl 1,4-diethyl-2,5-dimethoxybenzene-ω,ω,ω',ω'-tetracarboxylate

1,4-Dimethoxy-2,5-bis-iodmethyl-benzol

1,4-bis(acetoxymethyl)-2,5-dimethoxybenzene

Refernces

• 1、 Liu, Huan,Fu, Yanyan,Xu, Wei,He, Qingguo,Cao, Huimin,Liu, Guohua,Cheng, Jiangong. "Microcrystal induced emission enhancement of a small molecule probe and its use for highly efficient detection of 2,4,6-trinitrophenol in water". . p. 857 - 862. Retrieved 2018.
• 2、 Chen, Hongli,Chen, Xingguo,Lv, Wenjuan,Pan, Congjie,Wang, Guoxiu. "Synthesis of a novel chiral DA-TD covalent organic framework for open-tubular capillary electrochromatography enantioseparation". supporting information. p. 403 - 406. Retrieved 2022/01/19.
• 3、 Chen, Zhuang-Zhuang,Deng, Yun-Hu,Zhang, Ting,Dong, Wen-Kui. "A novel bifunctional-group salamo-like multi-purpose dye probe based on ESIPT and RAHB effect: Distinction of cyanide and hydrazine through optical signal differential protocol". supporting information. . Retrieved 2021/06/29.