Technology Process of Quinoline, 6-chloro-5-nitro-, 1-oxide
There total 1 articles about Quinoline, 6-chloro-5-nitro-, 1-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: trichlorophosphate / 12 h / 0 - 20 °C
2.1: water; iron; ammonium chloride / ethanol / 4 h / 65 °C
3.1: dmap; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1-methyl-pyrrolidin-2-one / 10 h / 50 °C
4.1: tetrahydrofuran / 2 h / Heating / reflux
4.2: 0.25 h / 20 °C
4.3: 4 h / 70 °C
5.1: trifluoroacetic acid / dichloromethane / 2 h
6.1: butyraldehyde / acetic acid / tetrahydrofuran / 0.5 h / 100 °C / Microwabe heating
7.1: sodium triacetoxyborohydride / tetrahydrofuran / 12 h
With
dmap; sodium triacetoxyborohydride; water; iron; ammonium chloride; butyraldehyde; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; trichlorophosphate;
acetic acid;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: trichlorophosphate / 12 h / 0 - 20 °C
2.1: water; iron; ammonium chloride / ethanol / 4 h / 65 °C
3.1: dmap; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1-methyl-pyrrolidin-2-one / 10 h / 50 °C
4.1: tetrahydrofuran / 2 h / Heating / reflux
4.2: 0.25 h / 20 °C
4.3: 4 h / 70 °C
5.1: trifluoroacetic acid / dichloromethane / 2 h
6.1: butyraldehyde / acetic acid / tetrahydrofuran / 0.5 h / 100 °C / Microwabe heating
7.1: sodium triacetoxyborohydride / tetrahydrofuran / 12 h
8.1: hydrogenchloride / 1,4-dioxane
With
hydrogenchloride; dmap; sodium triacetoxyborohydride; water; iron; ammonium chloride; butyraldehyde; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; trichlorophosphate;
acetic acid;
In
tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane;