2-Propenamide, 3-phenyl-N-(phenylmethyl)-

Base Information

• Chemical Name: 2-Propenamide, 3-phenyl-N-(phenylmethyl)-
• CAS No.: 57152-94-0
• Molecular Formula: C16H15NO
• Molecular Weight: 237.301
• Mol file: 57152-94-0.mol

Synonyms:

Chemical Property of 2-Propenamide, 3-phenyl-N-(phenylmethyl)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenamide, 3-phenyl-N-(phenylmethyl)-

There total 87 articles about 2-Propenamide, 3-phenyl-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-3-phenylacrylic acid (140-10-3) + benzylamine (100-46-9) → (E)-N-benzylcinnamamide (57152-94-0,104047-17-8,5100-00-5)

Guidance literature:

With boric acid; In toluene; for 5h; Heating;

DOI:10.1055/s-2008-1032039

Reference yield: 98.0%

N-benzyl-N-tosylcinnamamide → N-benzylcinnamamide (57152-94-0)

Guidance literature:

With 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole; In acetonitrile; at 20 ℃; for 8h; Irradiation;

DOI:10.1055/s-2005-872693

Reference yield: 97.0%

Cinnamic acid (621-82-9) + benzylamine (100-46-9) → N-benzylcinnamamide (57152-94-0)

Guidance literature:

With mesocellular siliceous foam-supported boronic acid catalyst; In o-xylene; at 155 ℃; for 5h; Sealed tube;

DOI:10.1039/c4cc01148a

upstream raw materials:

Cinnamic acid

benzylamine

C₂₁H₁₆N₂O₂

cinnamoyl chloride

Downstream raw materials:

trans-N-benzylthiocinnamamide

Refernces

• 1、 Fu, Zhengqiang,Wang, Xinghua,Tao, Sheng,Bu, Qingqing,Wei, Donghui,Liu, Ning. "Manganese Catalyzed Direct Amidation of Esters with Amines". . p. 2339 - 2358. Retrieved 2021/02/03.
• 2、 Ramachandran, P. Veeraraghavan,Hamann, Henry J.. "Ammonia-borane as a Catalyst for the Direct Amidation of Carboxylic Acids". supporting information. p. 2938 - 2942. Retrieved 2021/05/04.