N-Methyl-1-[4-(trifluoromethyl)phenyl]ethylamine

Base Information

• Chemical Name: N-Methyl-1-[4-(trifluoromethyl)phenyl]ethylamine
• CAS No.: 574731-05-8
• Molecular Formula: C10H12F3N
• Molecular Weight: 203.21
• Hs Code.: 2921490090
• Mol file: 574731-05-8.mol

Synonyms:

Chemical Property of N-Methyl-1-[4-(trifluoromethyl)phenyl]ethylamine

Chemical Property:

• Boiling Point: 201.5±35.0 °C(Predicted)
• PKA: 8.96±0.10(Predicted)
• Density: 1.117±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

methyl({1-[4-(trifluoromethyl)phenyl]ethyl})amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Methyl-1-[4-(trifluoromethyl)phenyl]ethylamine

There total 5 articles about N-Methyl-1-[4-(trifluoromethyl)phenyl]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C18H20F3N (672906-92-2) → (S)-N-methyl-1-(4-(trifluoromethyl)phenyl)ethan-1-amine (672906-71-7,574731-05-8)

Guidance literature:

C₁₈H₂₀F₃N; With hydrogen; acetic acid; 5%-palladium/activated carbon; In methanol; water; at 60 ℃; for 13.5h; under 3750.38 Torr;

With sodium hydroxide; In water;

Reference yield:

(E)-N-methyl-1-(4-(trifluoromethyl)phenyl)ethan-1-imine → (S)-N-methyl-1-(4-(trifluoromethyl)phenyl)ethan-1-amine (672906-71-7,574731-05-8)

Guidance literature:

With C₃₂H₁₂BF₂₄^(1-)*C₃₃H₅₂IrN₃O₂P⁽¹⁺⁾; hydrogen; In dichloromethane; at -10 ℃; under 2250.23 Torr; enantioselective reaction;

DOI:10.1021/jacs.8b11547

Reference yield:

N-methyl-[1-(4'-trifluoromethylphenyl)ethylidene]amine → N-methyl-1-(4-(trifluoromethyl)phenyl)ethanamine (574731-05-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201504052

upstream raw materials:

1-(4-trifluoromethylphenyl)ethanone

methylamine

C₁₈H₂₀F₃N

Refernces

• 1、 Li, Yan,Wang, Rui,Wang, Tao,Cheng, Xiu-Fen,Zhou, Xin,Fei, Fan,Wang, Xi-Sheng. "A Copper-Catalyzed Aerobic [1,3]-Nitrogen Shift through Nitrogen-Radical 4-exo-trig Cyclization". supporting information. p. 15436 - 15440. Retrieved 2017/11/01.
• 2、 -. "OPTICALLY ACTIVE 1-(FLUORO-,TRIFLUOROMETHYL-OR TRIFLUOROMETHOXY-SUBSTITUTED PHENYL)ALKYLAMINE N-MONOALKYL DERIVATIVES AND PROCESS FOR PRODUCING SAME". Page 42-43. . Retrieved 2010/02/06.