2-Chloro-6-hydroxyquinoline

Base Information

• Chemical Name: 2-Chloro-6-hydroxyquinoline
• CAS No.: 577967-89-6
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.606
• Hs Code.: 2933499090
• Mol file: 577967-89-6.mol

Synonyms:2-Chloroquinolin-6-ol;

Chemical Property of 2-Chloro-6-hydroxyquinoline

Chemical Property:

• Melting Point: 342.054 °C at 760 mmHg
• Boiling Point: 160.669 °C
• PKA: 8.62±0.40(Predicted)
• PSA: 33.12000
• Density: 1.412 g/cm³
• LogP: 2.59380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Acetonitrile (Slightly), DMSO (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-Chloroquinolin-6-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloroquinolin-6-ol can be used for hair dye compositions.

Technology Process of 2-Chloro-6-hydroxyquinoline

There total 6 articles about 2-Chloro-6-hydroxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

quinoline-2,6-diol (19315-93-6) → 6-hydroxy-2-chloroquinoline (577967-89-6)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.09.069

Reference yield: 93.0%

2-chloro-6-methoxyquinoline (13676-02-3) → 6-hydroxy-2-chloroquinoline (577967-89-6)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 15h;

Reference yield: 93.0%

→ 6-hydroxy-2-chloroquinoline (577967-89-6)

Guidance literature:

upstream raw materials:

2-chloro-6-methoxyquinoline

quinoline-2,6-diol

6-methoxyquinoline N-oxide

6-methoxy quinoline

Downstream raw materials:

6-(benzyloxy)-2-chloroquinoline

2-chloro-6-(3-methoxy-benzyloxy)-quinoline

2-chloro-6-(4-fluoro-benzyloxy)-quinoline

2-chloro-4-(6-hydroxyquinolin-2-yl)benzoic acid

Refernces

• 1、 -. "For detecting imaging agent of neurological disorders". Paragraph 0906-0908. . Retrieved 2016/10/08.
• 2、 -. "TAU IMAGING PROBE". Paragraph 0263. . Retrieved 2016/09/26.